RHAR_SALTY
ID RHAR_SALTY Reviewed; 282 AA.
AC P40865;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 13-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=HTH-type transcriptional activator RhaR {ECO:0000255|HAMAP-Rule:MF_01533};
DE AltName: Full=L-rhamnose operon transcriptional activator RhaR {ECO:0000255|HAMAP-Rule:MF_01533};
GN Name=rhaR {ECO:0000255|HAMAP-Rule:MF_01533}; Synonyms=rhaC1;
GN OrderedLocusNames=STM4049;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 177-282.
RC STRAIN=C5;
RX PubMed=1551902; DOI=10.1016/s0021-9258(19)50517-8;
RA Tate C.G., Muiry J.A.R., Henderson P.J.F.;
RT "Mapping, cloning, expression, and sequencing of the rhaT gene, which
RT encodes a novel L-rhamnose-H+ transport protein in Salmonella typhimurium
RT and Escherichia coli.";
RL J. Biol. Chem. 267:6923-6932(1992).
CC -!- FUNCTION: Activates expression of the rhaSR operon in response to L-
CC rhamnose. {ECO:0000255|HAMAP-Rule:MF_01533}.
CC -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000255|HAMAP-Rule:MF_01533}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01533}.
CC -!- SEQUENCE CAUTION:
CC Sequence=M85157; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE006468; AAL22889.1; -; Genomic_DNA.
DR EMBL; M85157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_462930.1; NC_003197.2.
DR RefSeq; WP_000013290.1; NC_003197.2.
DR AlphaFoldDB; P40865; -.
DR SMR; P40865; -.
DR STRING; 99287.STM4049; -.
DR PaxDb; P40865; -.
DR EnsemblBacteria; AAL22889; AAL22889; STM4049.
DR GeneID; 1255576; -.
DR KEGG; stm:STM4049; -.
DR PATRIC; fig|99287.12.peg.4266; -.
DR HOGENOM; CLU_000445_88_5_6; -.
DR OMA; NREVGMT; -.
DR PhylomeDB; P40865; -.
DR BioCyc; SENT99287:STM4049-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR GO; GO:0019299; P:rhamnose metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.120.10; -; 1.
DR HAMAP; MF_01533; HTH_type_RhaR; 1.
DR InterPro; IPR003313; AraC-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR InterPro; IPR023699; Tscrpt_act_RhaR.
DR InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR Pfam; PF02311; AraC_binding; 1.
DR Pfam; PF12833; HTH_18; 1.
DR PRINTS; PR00032; HTHARAC.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF51182; SSF51182; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Reference proteome; Repeat;
KW Rhamnose metabolism; Transcription; Transcription regulation.
FT CHAIN 1..282
FT /note="HTH-type transcriptional activator RhaR"
FT /id="PRO_0000194559"
FT DOMAIN 179..277
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
FT DNA_BIND 196..217
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
FT DNA_BIND 244..267
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
FT SITE 246
FT /note="Interaction with sigma-70"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01533"
SQ SEQUENCE 282 AA; 32858 MW; 657BF8FE7DE1CF20 CRC64;
MANQLILLKK DFFTDEQQAV TVADRYPQDV FAEHTHEFCE LVMVWRGNGL HVLNERPYRI
TRGDLFYIRA EDKHSYTSVN DLVLQNIIYC PERLKLNVNW QAMIPGFQGA QWHPHWRLGS
MGMNQARQVI NQLEHESNGR DPLANEMAEL LFGQLVMTLK RHRYATDDLP ATSRETLLDK
LITALANSLE CPFALDAFCQ QEQCSERVLR QQFRAQTGMT INQYLRQVRI CHAQYLLQHS
PLMISEISMQ CGFEDSNYFS VVFTRETGMT PSQWRHLSNQ SD
