ID   RHAS_SALPC              Reviewed;         278 AA.
AC   C0Q3L4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=HTH-type transcriptional activator RhaS {ECO:0000255|HAMAP-Rule:MF_01534};
DE   AltName: Full=L-rhamnose operon regulatory protein RhaS {ECO:0000255|HAMAP-Rule:MF_01534};
GN   Name=rhaS {ECO:0000255|HAMAP-Rule:MF_01534}; OrderedLocusNames=SPC_4152;
OS   Salmonella paratyphi C (strain RKS4594).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=476213;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RKS4594;
RX   PubMed=19229335; DOI=10.1371/journal.pone.0004510;
RA   Liu W.-Q., Feng Y., Wang Y., Zou Q.-H., Chen F., Guo J.-T., Peng Y.-H.,
RA   Jin Y., Li Y.-G., Hu S.-N., Johnston R.N., Liu G.-R., Liu S.-L.;
RT   "Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis
RT   and pathogenic convergence with Salmonella typhi.";
RL   PLoS ONE 4:E4510-E4510(2009).
CC   -!- FUNCTION: Activates expression of the rhaBAD and rhaT operons.
CC       {ECO:0000255|HAMAP-Rule:MF_01534}.
CC   -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000255|HAMAP-Rule:MF_01534}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01534}.
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DR   EMBL; CP000857; ACN48216.1; -; Genomic_DNA.
DR   RefSeq; WP_000217112.1; NC_012125.1.
DR   AlphaFoldDB; C0Q3L4; -.
DR   SMR; C0Q3L4; -.
DR   EnsemblBacteria; ACN48216; ACN48216; SPC_4152.
DR   KEGG; sei:SPC_4152; -.
DR   HOGENOM; CLU_000445_88_5_6; -.
DR   OMA; GHYPSHW; -.
DR   Proteomes; UP000001599; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0019299; P:rhamnose metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   HAMAP; MF_01534; HTH_type_RhaS; 1.
DR   InterPro; IPR003313; AraC-bd.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR037923; HTH-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   InterPro; IPR023609; Tscrpt_reg_HTH_RhaS.
DR   Pfam; PF02311; AraC_binding; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF51215; SSF51215; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repeat; Rhamnose metabolism;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..278
FT                   /note="HTH-type transcriptional activator RhaS"
FT                   /id="PRO_1000185180"
FT   DOMAIN          174..272
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01534"
FT   DNA_BIND        191..212
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01534"
FT   DNA_BIND        239..262
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01534"
FT   SITE            241
FT                   /note="Interaction with sigma-70"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01534"
FT   SITE            250
FT                   /note="Interaction with sigma-70"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01534"
SQ   SEQUENCE   278 AA;  32089 MW;  A8451BF20C1F4297 CRC64;
     MTVLHSVDFF PSGKAPVAIE PRLPQAAFPE HHHDFHEIVI VEHGTGIHVF NGQPYTISGG
     TVCFVRDHDR HLYEHTDNLC LTNVLWRSPD AFQFLAGLDQ LLPQEQDGYY PSHWRVNQSV
     LQQVRQLVGL MERAGDGMDA PAVANREILF MQLLVLLRRS SLMEGATNND AKLNQLMAWL
     EDHFAEEVCW EAVAEQFSLS LRTLHRQLKQ HTGLTPQRYL NRLRLIKARH LLRHSDHSVT
     EIAYRCGFGD SNHFSTLFRR EFNWSPRDIR QGRDAIIQ