ID   RHAT_ECOL6              Reviewed;         344 AA.
AC   Q8FBD6;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=L-rhamnose-proton symporter {ECO:0000255|HAMAP-Rule:MF_01532};
DE   AltName: Full=L-rhamnose-H(+) transport protein {ECO:0000255|HAMAP-Rule:MF_01532};
GN   Name=rhaT {ECO:0000255|HAMAP-Rule:MF_01532}; OrderedLocusNames=c4857;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Uptake of L-rhamnose across the cytoplasmic membrane with the
CC       concomitant transport of protons into the cell (symport system).
CC       {ECO:0000255|HAMAP-Rule:MF_01532}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-
CC         rhamnopyranose(out); Xref=Rhea:RHEA:29947, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:62346; Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29949;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01532}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01532}.
CC   -!- SIMILARITY: Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01532}.
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DR   EMBL; AE014075; AAN83285.1; -; Genomic_DNA.
DR   RefSeq; WP_000063507.1; NC_004431.1.
DR   AlphaFoldDB; Q8FBD6; -.
DR   STRING; 199310.c4857; -.
DR   EnsemblBacteria; AAN83285; AAN83285; c4857.
DR   KEGG; ecc:c4857; -.
DR   eggNOG; ENOG502Z7ID; Bacteria.
DR   HOGENOM; CLU_066437_0_0_6; -.
DR   OMA; QFFFYGM; -.
DR   BioCyc; ECOL199310:C4857-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015153; F:rhamnose transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   HAMAP; MF_01532; RhaT; 1.
DR   InterPro; IPR004673; L-rhamnose-proton_sym_RhaT.
DR   Pfam; PF06379; RhaT; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Sugar transport; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..344
FT                   /note="L-rhamnose-proton symporter"
FT                   /id="PRO_0000208274"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
SQ   SEQUENCE   344 AA;  37284 MW;  CF4BF7AEE78C657E CRC64;
     MSNAITMGIF WHLIGAASAA CFYAPFKKVK KWSWETMWSV GGIVSWIILP WAISALLLPN
     FWAYYSSFSL STLLPVFLFG AMWGIGNINY GLTMRYLGMS MGIGIAIGIT LIVGTLMTPI
     INGNFDVLIN TEGGRMTLLG VLVALIGVGI VTRAGQLKER KMGIKAEEFN LKKGLVLAVM
     CGIFSAGMSF AMNAAKPMHE AAAALGVDPL YVALPSYVVI MGGGAIINLG FCFIRLAKVK
     DLSLKADFSL AKPLIIHNVL LSALGGLMWY LQFFFYAWGH ARIPAQYDYI SWMLHMSFYV
     LCGGIVGLVL KEWNNAGRRP VTVLSLGCVV IIVAANIVGI GMAN