RHAT_ECOLC
ID RHAT_ECOLC Reviewed; 344 AA.
AC B1IVH1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=L-rhamnose-proton symporter {ECO:0000255|HAMAP-Rule:MF_01532};
DE AltName: Full=L-rhamnose-H(+) transport protein {ECO:0000255|HAMAP-Rule:MF_01532};
GN Name=rhaT {ECO:0000255|HAMAP-Rule:MF_01532}; OrderedLocusNames=EcolC_4110;
OS Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 /
OS WDCM 00012 / Crooks).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=481805;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Ingram L., Richardson P.;
RT "Complete sequence of Escherichia coli C str. ATCC 8739.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-rhamnose across the cytoplasmic membrane with the
CC concomitant transport of protons into the cell (symport system).
CC {ECO:0000255|HAMAP-Rule:MF_01532}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-
CC rhamnopyranose(out); Xref=Rhea:RHEA:29947, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:62346; Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29949;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01532}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01532}.
CC -!- SIMILARITY: Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
CC {ECO:0000255|HAMAP-Rule:MF_01532}.
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DR EMBL; CP000946; ACA79708.1; -; Genomic_DNA.
DR RefSeq; WP_000063515.1; NZ_CP022959.1.
DR AlphaFoldDB; B1IVH1; -.
DR KEGG; ecl:EcolC_4110; -.
DR HOGENOM; CLU_066437_0_0_6; -.
DR OMA; QFFFYGM; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015153; F:rhamnose transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR HAMAP; MF_01532; RhaT; 1.
DR InterPro; IPR004673; L-rhamnose-proton_sym_RhaT.
DR Pfam; PF06379; RhaT; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Sugar transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..344
FT /note="L-rhamnose-proton symporter"
FT /id="PRO_1000087594"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
SQ SEQUENCE 344 AA; 37218 MW; F3BE7FA19DB43E2C CRC64;
MSNAITMGIF WHLIGAASAA CFYAPFKKVK KWSWETMWSV GGIVSWIILP WAISALLLPN
FWAYYSSFSL STLLPVFLFG AMWGIGNINY GLTMRYLGMS MGIGIAIGIT LIVGTLMTPI
INGNFDVLIS TEGGRMTLLG VLVALIGVGI VTRAGQLKER KMGIKAEEFN LKKGLVLAVM
CGIFSAGMSF AMNAAKPMHE AAAALGVDPL YVALPSYVVI MGGGAIINLG FCFIRLAKVK
DLSLKADFSL AKSLIIHNVL LSTLGGLMWY LQFFFYAWGH APIPAQYDYI SWMLHMSFYV
LCGGIVGLVL KEWNNAGRRP VTVLSLGCVV IIVAANIVGI GMAN