RHAT_ECOSM
ID RHAT_ECOSM Reviewed; 344 AA.
AC B1LMU8;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=L-rhamnose-proton symporter {ECO:0000255|HAMAP-Rule:MF_01532};
DE AltName: Full=L-rhamnose-H(+) transport protein {ECO:0000255|HAMAP-Rule:MF_01532};
GN Name=rhaT {ECO:0000255|HAMAP-Rule:MF_01532};
GN OrderedLocusNames=EcSMS35_4298;
OS Escherichia coli (strain SMS-3-5 / SECEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=439855;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMS-3-5 / SECEC;
RX PubMed=18708504; DOI=10.1128/jb.00661-08;
RA Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA Ravel J., Stepanauskas R.;
RT "Insights into the environmental resistance gene pool from the genome
RT sequence of the multidrug-resistant environmental isolate Escherichia coli
RT SMS-3-5.";
RL J. Bacteriol. 190:6779-6794(2008).
CC -!- FUNCTION: Uptake of L-rhamnose across the cytoplasmic membrane with the
CC concomitant transport of protons into the cell (symport system).
CC {ECO:0000255|HAMAP-Rule:MF_01532}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-
CC rhamnopyranose(out); Xref=Rhea:RHEA:29947, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:62346; Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29949;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01532}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01532}.
CC -!- SIMILARITY: Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
CC {ECO:0000255|HAMAP-Rule:MF_01532}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000970; ACB19540.1; -; Genomic_DNA.
DR RefSeq; WP_000063508.1; NC_010498.1.
DR AlphaFoldDB; B1LMU8; -.
DR EnsemblBacteria; ACB19540; ACB19540; EcSMS35_4298.
DR KEGG; ecm:EcSMS35_4298; -.
DR HOGENOM; CLU_066437_0_0_6; -.
DR OMA; QFFFYGM; -.
DR Proteomes; UP000007011; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015153; F:rhamnose transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR HAMAP; MF_01532; RhaT; 1.
DR InterPro; IPR004673; L-rhamnose-proton_sym_RhaT.
DR Pfam; PF06379; RhaT; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Sugar transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..344
FT /note="L-rhamnose-proton symporter"
FT /id="PRO_1000193744"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
SQ SEQUENCE 344 AA; 37302 MW; CF4BF7AEE14C657E CRC64;
MSNAITMGIF WHLIGAASAA CFYAPFKKVK KWSWETMWSV GGIVSWIILP WAISALLLPN
FWAYYSSFSL STLLPVFLFG AMWGIGNINY GLTMRYLGMS MGIGIAIGIT LIVGTLMTPI
INGNFDVLIN TEGGRMTLLG VLVALIGVGI VTRAGQLKER KMGIKAEEFN LKKGLVLAVM
CGIFSAGMSF AMNAAKPMHE AAAALGVDPL YVALPSYVVI MGGGAIINLG FCFIRLAKVK
DLSLKADFSL AKPLIIHNVL LSALGGLMWY LQFFFYAWGH ARIPAQYDYI SWMLHMSFYV
LCGGIVGLVL KEWNNAGRRP VTVLSLGCVV IIVAANIVGM GMAN