RHAT_SALSV
ID RHAT_SALSV Reviewed; 344 AA.
AC B4TPR1;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=L-rhamnose-proton symporter {ECO:0000255|HAMAP-Rule:MF_01532};
DE AltName: Full=L-rhamnose-H(+) transport protein {ECO:0000255|HAMAP-Rule:MF_01532};
GN Name=rhaT {ECO:0000255|HAMAP-Rule:MF_01532}; OrderedLocusNames=SeSA_A4264;
OS Salmonella schwarzengrund (strain CVM19633).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=439843;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CVM19633;
RX PubMed=21602358; DOI=10.1128/jb.00297-11;
RA Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA Leclerc J.E., Ravel J., Cebula T.A.;
RT "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT CRISPR-mediated adaptive sublineage evolution.";
RL J. Bacteriol. 193:3556-3568(2011).
CC -!- FUNCTION: Uptake of L-rhamnose across the cytoplasmic membrane with the
CC concomitant transport of protons into the cell (symport system).
CC {ECO:0000255|HAMAP-Rule:MF_01532}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-
CC rhamnopyranose(out); Xref=Rhea:RHEA:29947, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:62346; Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29949;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01532}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01532}.
CC -!- SIMILARITY: Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
CC {ECO:0000255|HAMAP-Rule:MF_01532}.
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DR EMBL; CP001127; ACF90968.1; -; Genomic_DNA.
DR RefSeq; WP_000063541.1; NC_011094.1.
DR AlphaFoldDB; B4TPR1; -.
DR EnsemblBacteria; ACF90968; ACF90968; SeSA_A4264.
DR KEGG; sew:SeSA_A4264; -.
DR HOGENOM; CLU_066437_0_0_6; -.
DR OMA; QFFFYGM; -.
DR Proteomes; UP000001865; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015153; F:rhamnose transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR HAMAP; MF_01532; RhaT; 1.
DR InterPro; IPR004673; L-rhamnose-proton_sym_RhaT.
DR Pfam; PF06379; RhaT; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Sugar transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..344
FT /note="L-rhamnose-proton symporter"
FT /id="PRO_1000146501"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
SQ SEQUENCE 344 AA; 37390 MW; C9B90BD9BC9541D9 CRC64;
MSNAITMGIF WHLIGAASAA CFYAPFKQVK QWSWETMWSV GGIVSWLILP WTISALLLPD
FWAYYGQFNL STLLPVFLFG AMWGIGNINY GLTMRYLGMS MGIGIAIGIT LIVGTLMTPI
INGNFDVLIH TEGGRMTLLG VFVALIGVGI VTRAGQLKER KMGIKAEEFN LKKGLLLAVM
CGIFSAGMSF AMNAAKPMHE AAAALGVDPL YVALPSYVVI MGGGALVNLG FCFIRLAKVQ
NLSIKADFSL ARPLIISNIL LSALGGLMWY LQFFFYAWGH ARIPAQYDYM SWMLHMSFYV
LCGGLVGLVL KEWKNAGRRP VAVLSLGCVV IIIAANIVGL GMAS