RHAT_SHIFL
ID RHAT_SHIFL Reviewed; 344 AA.
AC Q83PD8;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 3.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=L-rhamnose-proton symporter {ECO:0000255|HAMAP-Rule:MF_01532};
DE AltName: Full=L-rhamnose-H(+) transport protein {ECO:0000255|HAMAP-Rule:MF_01532};
GN Name=rhaT {ECO:0000255|HAMAP-Rule:MF_01532};
GN OrderedLocusNames=SF3984, S3764;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Uptake of L-rhamnose across the cytoplasmic membrane with the
CC concomitant transport of protons into the cell (symport system).
CC {ECO:0000255|HAMAP-Rule:MF_01532}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-
CC rhamnopyranose(out); Xref=Rhea:RHEA:29947, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:62346; Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29949;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01532};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01532}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01532}.
CC -!- SIMILARITY: Belongs to the L-rhamnose transporter (TC 2.A.7.6) family.
CC {ECO:0000255|HAMAP-Rule:MF_01532}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN45418.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=AE014073; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE005674; AAN45418.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AE014073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q83PD8; -.
DR STRING; 198214.SF3984; -.
DR EnsemblBacteria; AAN45418; AAN45418; SF3984.
DR HOGENOM; CLU_066437_0_0_6; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015153; F:rhamnose transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR HAMAP; MF_01532; RhaT; 1.
DR InterPro; IPR004673; L-rhamnose-proton_sym_RhaT.
DR Pfam; PF06379; RhaT; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..344
FT /note="L-rhamnose-proton symporter"
FT /id="PRO_0000208281"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01532"
SQ SEQUENCE 344 AA; 37315 MW; C96DB5CCF15528FC CRC64;
MSNAITMGIF WHLIGAASAA CFYAPFKKVK KWSWETMWSV GGIVSWIILP WAISALLLPD
FWAYYSSFSL STLLPVFLFG AMWGIGNINY GLTMRYLGMS MGIGIAIGIT LIVGTLMTPI
INGNFDVLIN TEGGRMTLLG VLVALIGVGI VTRAGQLKER KMGIKAEEFN LKKGLVLAVM
CGIFSAGMSF AMNAAKPMHE AAAALGVDPL YVALPSYVVI MGGGAIINLG FCFIRLAKVK
DLSLKADFSL AKPLIIHNVL LSALGGLMWY LQFFFYAWGH ARIPAQYDYI SWMLHMSFYV
LCGGIVGLVL KEWNNTGRRP VTVLSLGCVV IIVAANIVGI GMAN
