RHBD2_HUMAN
ID RHBD2_HUMAN Reviewed; 364 AA.
AC Q6NTF9; Q7L534; Q9H5W6; Q9HBK7; Q9UDT2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Rhomboid domain-containing protein 2;
GN Name=RHBDD2; Synonyms=RHBDL7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Pituitary;
RA Xiao H., Song H., Gao G., Ren S., Chen Z., Han Z.;
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANT HIS-85.
RX PubMed=23386608; DOI=10.1074/jbc.m112.419960;
RA Ahmedli N.B., Gribanova Y., Njoku C.C., Naidu A., Young A., Mendoza E.,
RA Yamashita C.K., Ozgul R.K., Johnson J.E., Fox D.A., Farber D.B.;
RT "Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina
RT and involvement of its human ortholog in retinitis pigmentosa.";
RL J. Biol. Chem. 288:9742-9754(2013).
CC -!- INTERACTION:
CC Q6NTF9-3; O95870: ABHD16A; NbExp=3; IntAct=EBI-17589229, EBI-348517;
CC Q6NTF9-3; Q13085-4: ACACA; NbExp=3; IntAct=EBI-17589229, EBI-12562760;
CC Q6NTF9-3; Q96CM8: ACSF2; NbExp=3; IntAct=EBI-17589229, EBI-2876502;
CC Q6NTF9-3; Q07817: BCL2L1; NbExp=3; IntAct=EBI-17589229, EBI-78035;
CC Q6NTF9-3; Q92843: BCL2L2; NbExp=3; IntAct=EBI-17589229, EBI-707714;
CC Q6NTF9-3; Q9H5X1: CIAO2A; NbExp=3; IntAct=EBI-17589229, EBI-752069;
CC Q6NTF9-3; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-17589229, EBI-7062247;
CC Q6NTF9-3; P27658: COL8A1; NbExp=3; IntAct=EBI-17589229, EBI-747133;
CC Q6NTF9-3; P21964: COMT; NbExp=3; IntAct=EBI-17589229, EBI-372265;
CC Q6NTF9-3; Q9NR28: DIABLO; NbExp=3; IntAct=EBI-17589229, EBI-517508;
CC Q6NTF9-3; Q6P2H7: DYNC1H1; NbExp=3; IntAct=EBI-17589229, EBI-17590191;
CC Q6NTF9-3; Q14318: FKBP8; NbExp=3; IntAct=EBI-17589229, EBI-724839;
CC Q6NTF9-3; P31512: FMO4; NbExp=3; IntAct=EBI-17589229, EBI-17589491;
CC Q6NTF9-3; Q96A11: GAL3ST3; NbExp=3; IntAct=EBI-17589229, EBI-17590461;
CC Q6NTF9-3; P23434: GCSH; NbExp=3; IntAct=EBI-17589229, EBI-715444;
CC Q6NTF9-3; Q5U4N7: GDF5-AS1; NbExp=3; IntAct=EBI-17589229, EBI-17590774;
CC Q6NTF9-3; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-17589229, EBI-739467;
CC Q6NTF9-3; P33778: H2BC3; NbExp=3; IntAct=EBI-17589229, EBI-357986;
CC Q6NTF9-3; Q99525: H4C7; NbExp=3; IntAct=EBI-17589229, EBI-10294329;
CC Q6NTF9-3; P04792: HSPB1; NbExp=3; IntAct=EBI-17589229, EBI-352682;
CC Q6NTF9-3; Q96BM0: IFI27L1; NbExp=3; IntAct=EBI-17589229, EBI-17589287;
CC Q6NTF9-3; P24001: IL32; NbExp=3; IntAct=EBI-17589229, EBI-2866752;
CC Q6NTF9-3; O60333-2: KIF1B; NbExp=3; IntAct=EBI-17589229, EBI-10975473;
CC Q6NTF9-3; Q6P1Q0: LETMD1; NbExp=3; IntAct=EBI-17589229, EBI-1549822;
CC Q6NTF9-3; P27338: MAOB; NbExp=3; IntAct=EBI-17589229, EBI-3911344;
CC Q6NTF9-3; Q5VZR4: MFSD14C; NbExp=3; IntAct=EBI-17589229, EBI-2867865;
CC Q6NTF9-3; Q5XKP0: MICOS13; NbExp=3; IntAct=EBI-17589229, EBI-1053887;
CC Q6NTF9-3; Q96C03-3: MIEF2; NbExp=3; IntAct=EBI-17589229, EBI-11988931;
CC Q6NTF9-3; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-17589229, EBI-8852072;
CC Q6NTF9-3; Q9H8L6: MMRN2; NbExp=3; IntAct=EBI-17589229, EBI-2623273;
CC Q6NTF9-3; O95563: MPC2; NbExp=3; IntAct=EBI-17589229, EBI-719403;
CC Q6NTF9-3; Q6IN84: MRM1; NbExp=3; IntAct=EBI-17589229, EBI-5454865;
CC Q6NTF9-3; Q9NZE8-2: MRPL35; NbExp=3; IntAct=EBI-17589229, EBI-17590278;
CC Q6NTF9-3; Q96E29: MTERF3; NbExp=3; IntAct=EBI-17589229, EBI-7825321;
CC Q6NTF9-3; Q9HB07: MYG1; NbExp=3; IntAct=EBI-17589229, EBI-709754;
CC Q6NTF9-3; Q9Y3Q0: NAALAD2; NbExp=3; IntAct=EBI-17589229, EBI-2863682;
CC Q6NTF9-3; Q69YL0: NCBP2AS2; NbExp=3; IntAct=EBI-17589229, EBI-10986258;
CC Q6NTF9-3; Q9ULP0-2: NDRG4; NbExp=3; IntAct=EBI-17589229, EBI-11978907;
CC Q6NTF9-3; Q9UMS0: NFU1; NbExp=3; IntAct=EBI-17589229, EBI-725252;
CC Q6NTF9-3; Q8IXM6: NRM; NbExp=3; IntAct=EBI-17589229, EBI-10262547;
CC Q6NTF9-3; Q96AL5: PBX3; NbExp=3; IntAct=EBI-17589229, EBI-741171;
CC Q6NTF9-3; P17612: PRKACA; NbExp=3; IntAct=EBI-17589229, EBI-476586;
CC Q6NTF9-3; P54725: RAD23A; NbExp=3; IntAct=EBI-17589229, EBI-746453;
CC Q6NTF9-3; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-17589229, EBI-396669;
CC Q6NTF9-3; P60602: ROMO1; NbExp=3; IntAct=EBI-17589229, EBI-11909831;
CC Q6NTF9-3; Q8WXG1: RSAD2; NbExp=3; IntAct=EBI-17589229, EBI-12736320;
CC Q6NTF9-3; Q96QR1: SCGB3A1; NbExp=3; IntAct=EBI-17589229, EBI-9057632;
CC Q6NTF9-3; O14521: SDHD; NbExp=3; IntAct=EBI-17589229, EBI-1224553;
CC Q6NTF9-3; P50454: SERPINH1; NbExp=3; IntAct=EBI-17589229, EBI-350723;
CC Q6NTF9-3; Q9BXI2: SLC25A2; NbExp=3; IntAct=EBI-17589229, EBI-17590310;
CC Q6NTF9-3; Q00325-2: SLC25A3; NbExp=3; IntAct=EBI-17589229, EBI-5456178;
CC Q6NTF9-3; O15079: SNPH; NbExp=3; IntAct=EBI-17589229, EBI-4401902;
CC Q6NTF9-3; Q17RD7: SYT16; NbExp=3; IntAct=EBI-17589229, EBI-10238936;
CC Q6NTF9-3; Q53QW1: TEX44; NbExp=3; IntAct=EBI-17589229, EBI-10278496;
CC Q6NTF9-3; P37173: TGFBR2; NbExp=3; IntAct=EBI-17589229, EBI-296151;
CC Q6NTF9-3; P07204: THBD; NbExp=3; IntAct=EBI-17589229, EBI-941422;
CC Q6NTF9-3; O60830: TIMM17B; NbExp=3; IntAct=EBI-17589229, EBI-2372529;
CC Q6NTF9-3; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-17589229, EBI-17249488;
CC Q6NTF9-3; Q2NL82: TSR1; NbExp=3; IntAct=EBI-17589229, EBI-358058;
CC Q6NTF9-3; A0A384ME17: TUFM; NbExp=3; IntAct=EBI-17589229, EBI-12261790;
CC Q6NTF9-3; Q05086-3: UBE3A; NbExp=3; IntAct=EBI-17589229, EBI-11026619;
CC Q6NTF9-3; Q70CQ3: USP30; NbExp=3; IntAct=EBI-17589229, EBI-2512374;
CC Q6NTF9-3; O76024: WFS1; NbExp=3; IntAct=EBI-17589229, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6NTF9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NTF9-2; Sequence=VSP_055407;
CC Name=3;
CC IsoId=Q6NTF9-3; Sequence=VSP_055608;
CC -!- SIMILARITY: Belongs to the peptidase S54 family. {ECO:0000305}.
CC -!- CAUTION: Although strongly related to the peptidase S54 family, it
CC lacks the conserved active sites, suggesting that it has no peptidase
CC activity. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG09733.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAH06234.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF226732; AAG09733.1; ALT_FRAME; mRNA.
DR EMBL; AK026590; BAB15503.1; -; mRNA.
DR EMBL; AC005067; AAD45960.1; -; Genomic_DNA.
DR EMBL; BC006234; AAH06234.2; ALT_INIT; mRNA.
DR EMBL; BC069017; AAH69017.1; -; mRNA.
DR CCDS; CCDS43602.1; -. [Q6NTF9-1]
DR CCDS; CCDS43603.1; -. [Q6NTF9-3]
DR RefSeq; NP_001035546.1; NM_001040456.2. [Q6NTF9-1]
DR RefSeq; NP_001035547.1; NM_001040457.2. [Q6NTF9-3]
DR RefSeq; NP_001333115.1; NM_001346186.1. [Q6NTF9-3]
DR RefSeq; NP_001333116.1; NM_001346187.1. [Q6NTF9-3]
DR RefSeq; NP_001333117.1; NM_001346188.1.
DR RefSeq; XP_005250568.1; XM_005250511.4. [Q6NTF9-3]
DR AlphaFoldDB; Q6NTF9; -.
DR BioGRID; 121515; 111.
DR IntAct; Q6NTF9; 87.
DR MINT; Q6NTF9; -.
DR STRING; 9606.ENSP00000006777; -.
DR MEROPS; S54.955; -.
DR TCDB; 9.B.104.4.4; the rhomboid protease (rhomboid) family.
DR iPTMnet; Q6NTF9; -.
DR PhosphoSitePlus; Q6NTF9; -.
DR SwissPalm; Q6NTF9; -.
DR BioMuta; RHBDD2; -.
DR DMDM; 118595708; -.
DR EPD; Q6NTF9; -.
DR jPOST; Q6NTF9; -.
DR MassIVE; Q6NTF9; -.
DR MaxQB; Q6NTF9; -.
DR PaxDb; Q6NTF9; -.
DR PeptideAtlas; Q6NTF9; -.
DR PRIDE; Q6NTF9; -.
DR ProteomicsDB; 66673; -. [Q6NTF9-1]
DR Antibodypedia; 48862; 47 antibodies from 19 providers.
DR DNASU; 57414; -.
DR Ensembl; ENST00000006777.11; ENSP00000006777.6; ENSG00000005486.17. [Q6NTF9-1]
DR Ensembl; ENST00000318622.8; ENSP00000314144.4; ENSG00000005486.17. [Q6NTF9-3]
DR Ensembl; ENST00000428119.1; ENSP00000391232.1; ENSG00000005486.17. [Q6NTF9-3]
DR GeneID; 57414; -.
DR KEGG; hsa:57414; -.
DR MANE-Select; ENST00000006777.11; ENSP00000006777.6; NM_001040456.3; NP_001035546.1.
DR UCSC; uc003udv.1; human. [Q6NTF9-1]
DR CTD; 57414; -.
DR DisGeNET; 57414; -.
DR GeneCards; RHBDD2; -.
DR HGNC; HGNC:23082; RHBDD2.
DR HPA; ENSG00000005486; Tissue enhanced (brain).
DR MIM; 615203; gene.
DR neXtProt; NX_Q6NTF9; -.
DR OpenTargets; ENSG00000005486; -.
DR PharmGKB; PA134864375; -.
DR VEuPathDB; HostDB:ENSG00000005486; -.
DR eggNOG; KOG2632; Eukaryota.
DR GeneTree; ENSGT00390000000699; -.
DR HOGENOM; CLU_064872_1_0_1; -.
DR InParanoid; Q6NTF9; -.
DR OMA; HCFFTLI; -.
DR OrthoDB; 895980at2759; -.
DR PhylomeDB; Q6NTF9; -.
DR TreeFam; TF335461; -.
DR PathwayCommons; Q6NTF9; -.
DR SignaLink; Q6NTF9; -.
DR BioGRID-ORCS; 57414; 10 hits in 1075 CRISPR screens.
DR ChiTaRS; RHBDD2; human.
DR GenomeRNAi; 57414; -.
DR Pharos; Q6NTF9; Tbio.
DR PRO; PR:Q6NTF9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q6NTF9; protein.
DR Bgee; ENSG00000005486; Expressed in adenohypophysis and 168 other tissues.
DR ExpressionAtlas; Q6NTF9; baseline and differential.
DR Genevisible; Q6NTF9; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0000839; C:Hrd1p ubiquitin ligase ERAD-L complex; IBA:GO_Central.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR Gene3D; 1.20.1540.10; -; 1.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR Pfam; PF01694; Rhomboid; 1.
DR SUPFAM; SSF144091; SSF144091; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..364
FT /note="Rhomboid domain-containing protein 2"
FT /id="PRO_0000254596"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 242..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..141
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_055608"
FT VAR_SEQ 1
FT /note="M -> MGRGLWEAWPPAGSSAVAKGNCREEAEGAEDRQPASRRGAGTTAAM
FT (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_055407"
FT VARIANT 85
FT /note="R -> H (in dbSNP:rs11547498)"
FT /evidence="ECO:0000269|PubMed:23386608"
FT /id="VAR_051581"
FT CONFLICT 2
FT /note="A -> S (in Ref. 2; BAB15503)"
FT /evidence="ECO:0000305"
FT CONFLICT 77
FT /note="L -> P (in Ref. 4; AAH69017)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 364 AA; 39202 MW; 45C1E834218501F3 CRC64;
MAASGPGCRS WCLCPEVPSA TFFTALLSLL VSGPRLFLLQ QPLAPSGLTL KSEALRNWQV
YRLVTYIFVY ENPISLLCGA IIIWRFAGNF ERTVGTVRHC FFTVIFAIFS AIIFLSFEAV
SSLSKLGEVE DARGFTPVAF AMLGVTTVRS RMRRALVFGM VVPSVLVPWL LLGASWLIPQ
TSFLSNVCGL SIGLAYGLTY CYSIDLSERV ALKLDQTFPF SLMRRISVFK YVSGSSAERR
AAQSRKLNPV PGSYPTQSCH PHLSPSHPVS QTQHASGQKL ASWPSCTPGH MPTLPPYQPA
SGLCYVQNHF GPNPTSSSVY PASAGTSLGI QPPTPVNSPG TVYSGALGTP GAAGSKESSR
VPMP
