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RHBD3_MOUSE
ID   RHBD3_MOUSE             Reviewed;         385 AA.
AC   Q8BP97; A2RTD2; B7ZNK0; Q3U0Y4; Q5SUT5; Q5SUT6; Q5SUT7;
DT   02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Rhomboid domain-containing protein 3;
GN   Name=Rhbdd3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, and Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Czech II; TISSUE=Brain, and Lung tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8BP97-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BP97-2; Sequence=VSP_014669;
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DR   EMBL; AK077457; BAC36809.1; -; mRNA.
DR   EMBL; AK156451; BAE33717.1; -; mRNA.
DR   EMBL; AL645845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC096693; AAH96693.1; -; mRNA.
DR   EMBL; BC132459; AAI32460.1; -; mRNA.
DR   EMBL; BC145289; AAI45290.1; -; mRNA.
DR   CCDS; CCDS24397.1; -. [Q8BP97-1]
DR   CCDS; CCDS70133.1; -. [Q8BP97-2]
DR   RefSeq; NP_001277420.1; NM_001290491.1. [Q8BP97-2]
DR   RefSeq; NP_001277421.1; NM_001290492.1. [Q8BP97-1]
DR   RefSeq; NP_001277422.1; NM_001290493.1. [Q8BP97-1]
DR   RefSeq; NP_796344.1; NM_177370.4. [Q8BP97-1]
DR   RefSeq; XP_006514777.1; XM_006514714.3. [Q8BP97-1]
DR   RefSeq; XP_006514778.1; XM_006514715.2. [Q8BP97-1]
DR   RefSeq; XP_017170073.1; XM_017314584.1. [Q8BP97-2]
DR   AlphaFoldDB; Q8BP97; -.
DR   SMR; Q8BP97; -.
DR   BioGRID; 235012; 2.
DR   STRING; 10090.ENSMUSP00000099131; -.
DR   iPTMnet; Q8BP97; -.
DR   PhosphoSitePlus; Q8BP97; -.
DR   MaxQB; Q8BP97; -.
DR   PaxDb; Q8BP97; -.
DR   PRIDE; Q8BP97; -.
DR   ProteomicsDB; 253266; -. [Q8BP97-1]
DR   ProteomicsDB; 253267; -. [Q8BP97-2]
DR   Antibodypedia; 45284; 87 antibodies from 23 providers.
DR   DNASU; 279766; -.
DR   Ensembl; ENSMUST00000036320; ENSMUSP00000044703; ENSMUSG00000034175. [Q8BP97-2]
DR   Ensembl; ENSMUST00000101610; ENSMUSP00000099131; ENSMUSG00000034175. [Q8BP97-1]
DR   Ensembl; ENSMUST00000109878; ENSMUSP00000105504; ENSMUSG00000034175. [Q8BP97-1]
DR   GeneID; 279766; -.
DR   KEGG; mmu:279766; -.
DR   UCSC; uc007hwb.2; mouse. [Q8BP97-1]
DR   UCSC; uc007hwd.2; mouse. [Q8BP97-2]
DR   CTD; 25807; -.
DR   MGI; MGI:2444684; Rhbdd3.
DR   VEuPathDB; HostDB:ENSMUSG00000034175; -.
DR   eggNOG; KOG2632; Eukaryota.
DR   GeneTree; ENSGT00390000013711; -.
DR   HOGENOM; CLU_060547_0_0_1; -.
DR   InParanoid; Q8BP97; -.
DR   OMA; MYAGGIQ; -.
DR   PhylomeDB; Q8BP97; -.
DR   TreeFam; TF332785; -.
DR   BioGRID-ORCS; 279766; 1 hit in 74 CRISPR screens.
DR   ChiTaRS; Rhbdd3; mouse.
DR   PRO; PR:Q8BP97; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8BP97; protein.
DR   Bgee; ENSMUSG00000034175; Expressed in spermatocyte and 226 other tissues.
DR   ExpressionAtlas; Q8BP97; baseline and differential.
DR   Genevisible; Q8BP97; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0001889; P:liver development; IMP:MGI.
DR   GO; GO:0000165; P:MAPK cascade; IDA:MGI.
DR   GO; GO:0032815; P:negative regulation of natural killer cell activation; IMP:MGI.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.
DR   GO; GO:0002673; P:regulation of acute inflammatory response; IMP:MGI.
DR   GO; GO:0050708; P:regulation of protein secretion; IMP:MGI.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IMP:MGI.
DR   Gene3D; 1.20.1540.10; -; 1.
DR   InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR   InterPro; IPR041922; RHBDD3.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   InterPro; IPR015940; UBA.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR43066:SF16; PTHR43066:SF16; 1.
DR   Pfam; PF01694; Rhomboid; 1.
DR   Pfam; PF00627; UBA; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..385
FT                   /note="Rhomboid domain-containing protein 3"
FT                   /id="PRO_0000079570"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          322..361
FT                   /note="UBA"
FT   REGION          238..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         178..232
FT                   /note="YAAGAFQWLELSEQRLQVLQEGVLCKSLARCWPLRLFPTPGSLGELPVTYPA
FT                   GVR -> CRCCWGLPVAGALRAETAGVTGRCPLQVSGPMLAAEALSHPGQSG (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_014669"
SQ   SEQUENCE   385 AA;  40934 MW;  E2F8BB651B78B983 CRC64;
     MHAWEAPGSL SRALPLASSV LMLLLSCLWL LGAGPSLRLA PELLMEPWQV HRLLTHALGH
     TALPGLLLSL LLLPTLGWWQ ECHLGTVRFL HNSTVLALAT GLLAVLLAGL GVSGAAGGCG
     YMPVHLAMLA GQSHHPGWPQ RTLPPWLLPW LLLALTLLLS SEPPFLQLLC GLLTGLAYAA
     GAFQWLELSE QRLQVLQEGV LCKSLARCWP LRLFPTPGSL GELPVTYPAG VRPATPRPPY
     LASSDSWPHS DGSAQLPPRL GPGQLTWKNS ERGLDWAGSS FASATTMWAA LDEQMLQEGI
     QASLLDVSVQ GSQSSLWLPK PSVSSLRLQQ LQHMGFPTEQ AAVALAATGR VEGAVSLLVE
     GLVDTEALVT EGRSSPAHCT GTGAS
 
 
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