ID   RHBD3_RAT               Reviewed;         385 AA.
AC   Q642B3;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Rhomboid domain-containing protein 3;
GN   Name=Rhbdd3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC081912; AAH81912.1; -; mRNA.
DR   RefSeq; NP_001013897.1; NM_001013875.1.
DR   RefSeq; XP_006251266.1; XM_006251204.3.
DR   RefSeq; XP_006251267.1; XM_006251205.3.
DR   RefSeq; XP_006251268.1; XM_006251206.3.
DR   RefSeq; XP_006251269.1; XM_006251207.3.
DR   RefSeq; XP_006251270.1; XM_006251208.3.
DR   RefSeq; XP_006251271.1; XM_006251209.3.
DR   RefSeq; XP_006251272.1; XM_006251210.3.
DR   AlphaFoldDB; Q642B3; -.
DR   SMR; Q642B3; -.
DR   STRING; 10116.ENSRNOP00000032424; -.
DR   PaxDb; Q642B3; -.
DR   Ensembl; ENSRNOT00000031914; ENSRNOP00000032424; ENSRNOG00000027032.
DR   GeneID; 289753; -.
DR   KEGG; rno:289753; -.
DR   UCSC; RGD:1311827; rat.
DR   CTD; 25807; -.
DR   RGD; 1311827; Rhbdd3.
DR   eggNOG; KOG2632; Eukaryota.
DR   GeneTree; ENSGT00390000013711; -.
DR   HOGENOM; CLU_060547_0_0_1; -.
DR   InParanoid; Q642B3; -.
DR   OMA; MYAGGIQ; -.
DR   OrthoDB; 849873at2759; -.
DR   PhylomeDB; Q642B3; -.
DR   TreeFam; TF332785; -.
DR   PRO; PR:Q642B3; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000027032; Expressed in testis and 20 other tissues.
DR   Genevisible; Q642B3; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0001889; P:liver development; ISO:RGD.
DR   GO; GO:0000165; P:MAPK cascade; ISO:RGD.
DR   GO; GO:0032815; P:negative regulation of natural killer cell activation; ISO:RGD.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; ISO:RGD.
DR   GO; GO:0002673; P:regulation of acute inflammatory response; ISO:RGD.
DR   GO; GO:0050708; P:regulation of protein secretion; ISO:RGD.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; ISO:RGD.
DR   Gene3D; 1.20.1540.10; -; 1.
DR   InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR   InterPro; IPR041922; RHBDD3.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   InterPro; IPR015940; UBA.
DR   InterPro; IPR009060; UBA-like_sf.
DR   PANTHER; PTHR43066:SF16; PTHR43066:SF16; 1.
DR   Pfam; PF01694; Rhomboid; 1.
DR   Pfam; PF00627; UBA; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..385
FT                   /note="Rhomboid domain-containing protein 3"
FT                   /id="PRO_0000079571"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          322..361
FT                   /note="UBA"
SQ   SEQUENCE   385 AA;  41098 MW;  D467991AAA241220 CRC64;
     MHAWDPPASL SRALPLASSV LMLLLSCLWL LGAGPSLRLA PELLTEPWQV HRLLTHALGH
     TALPGLLLSL LLLPTLGWWQ ECHLGTLRFL HNSAVLALAT GLLAVLLAGL GLSSAAGGCG
     YMPVHLAMLA GQSYYPGWPQ RTLPPWLLPW LLLALTLLLS SEPPFLQLLC GLLAGLAYAA
     GAFRWLELSE RRLQVLQEGV LCRTLAGCWP LKLLPTPGSL GELPVTYPAG VRPATPRPPY
     LASSSSWPHT DGFAQLPPGL GPGQLTWKNS ERDLDWAGPS FASATPMWAA LDEQMLQEGI
     QASLLDVSVQ GSQNTLWSPK PSVSSLRLQQ LQHMGFPTEQ AAVALAATGR VEGAVSLLVE
     GLVDTEALVT EERSGPAHCK DTGVS