ID   RHBE_RHIME              Reviewed;         454 AA.
AC   Q9Z3Q8;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Rhizobactin siderophore biosynthesis protein RhbE;
DE            EC=1.-.-.-;
GN   Name=rhbE; Synonyms=rhsE; OrderedLocusNames=RA1262; ORFNames=SMa2408;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OG   Plasmid pSymA (megaplasmid 1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RCR2011 / SU47;
RX   PubMed=11274118; DOI=10.1128/jb.183.8.2576-2585.2001;
RA   Lynch D., O'Brien J., Welch T., Clarke P., Cuiv P.O., Crosa J.H.,
RA   O'Connell M.;
RT   "Genetic organization of the region encoding regulation, biosynthesis, and
RT   transport of rhizobactin 1021, a siderophore produced by Sinorhizobium
RT   meliloti.";
RL   J. Bacteriol. 183:2576-2585(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481432; DOI=10.1073/pnas.161294798;
RA   Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA   Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA   Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA   Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA   Long S.R.;
RT   "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT   meliloti pSymA megaplasmid.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- PATHWAY: Siderophore biosynthesis; rhizobactin biosynthesis.
CC   -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC       oxygenase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK65920.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF110737; AAD09416.1; -; Genomic_DNA.
DR   EMBL; AE006469; AAK65920.1; ALT_INIT; Genomic_DNA.
DR   PIR; F95419; F95419.
DR   PIR; T46818; T46818.
DR   RefSeq; NP_436508.1; NC_003037.1.
DR   AlphaFoldDB; Q9Z3Q8; -.
DR   SMR; Q9Z3Q8; -.
DR   EnsemblBacteria; AAK65920; AAK65920; SMa2408.
DR   KEGG; sme:SMa2408; -.
DR   PATRIC; fig|266834.11.peg.1315; -.
DR   HOGENOM; CLU_020931_0_0_5; -.
DR   BioCyc; MetaCyc:MON-15540; -.
DR   UniPathway; UPA00020; -.
DR   Proteomes; UP000001976; Plasmid pSymA.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019289; P:rhizobactin 1021 biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR031043; Histamin_N_OH.
DR   InterPro; IPR025700; Lys/Orn_oxygenase.
DR   PANTHER; PTHR42802; PTHR42802; 1.
DR   Pfam; PF13434; K_oxygenase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR04439; histamin_N_OH; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; NADP; Oxidoreductase; Plasmid; Reference proteome.
FT   CHAIN           1..454
FT                   /note="Rhizobactin siderophore biosynthesis protein RhbE"
FT                   /id="PRO_0000204034"
FT   BINDING         7..13
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   454 AA;  50212 MW;  57074278FF4FC1D1 CRC64;
     MTDFDLAGIG IGPFNLGLAA LLSSHENLSN VFLERKPAFR WHEGLILPGT TLQVPFMADL
     VTMADPTHRL SFLNYLAVHD RLYKFYFYEN FMIPRQEYDH YCRWASQQLS ACRFGEEVVD
     VAHESASDSF IVESRSASGG KQQYRSRNIA IGVGTAPFLP KWAQIKTLAP LMHSSEFGRR
     RLELSKRRRV TVIGSGQSAA ECVLALLNDL TPEMVAAGAS IQWITRSAGF FPMEYSKLGL
     EYFTPDYMRH FHRIAPVRRR EIVADQGLLY KGISFSTIGE IFDLMYERSV GGRDPGLALF
     SNCAVETLES AGGSGSFRIG INHNHLDEKA TVETDAIVAA TGYRHAWPEW LGSLKGSVLD
     TCEWGDLVVG GDFRARRSDG GKGHVFVQNA ETFHHGVGAP DLGLGAFRNA VIVNQLLGRE
     HYRVNASASF QKFGLPSSQT APSSISGDFY AHAS