RHBGB_XENLA
ID RHBGB_XENLA Reviewed; 460 AA.
AC Q6DCG4;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Ammonium transporter Rh type B-B;
DE AltName: Full=Rhesus blood group family type B glycoprotein B;
DE Short=Rh family type B glycoprotein B;
DE Short=Rh type B glycoprotein B;
GN Name=rhbg-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a specific ammonium transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000305}.
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DR EMBL; BC078079; AAH78079.1; -; mRNA.
DR RefSeq; NP_001087152.1; NM_001093683.1.
DR AlphaFoldDB; Q6DCG4; -.
DR SMR; Q6DCG4; -.
DR DNASU; 447041; -.
DR GeneID; 447041; -.
DR CTD; 447041; -.
DR Xenbase; XB-GENE-1009293; rhbg.S.
DR Proteomes; UP000186698; Genome assembly.
DR Bgee; 447041; Expressed in kidney and 12 other tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
PE 2: Evidence at transcript level;
KW Ammonia transport; Cell membrane; Cytoplasmic vesicle; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..460
FT /note="Ammonium transporter Rh type B-B"
FT /id="PRO_0000283611"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..87
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..252
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..283
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..394
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 416..460
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 460 AA; 50267 MW; 56AD4032CEBEBADA CRC64;
MTSYSTNMRI KLPLFCLLLQ FITIILFAVF VRYDHESDAR GWHEELNNHS SSNADNDFYY
RYPSFQDVHV MIFIGFGFLM TFLKRYGFSS VAFNFLIAAF GLQWSTLIQG FFHGFHDGKI
HVGIESMINA DFCTGAVLIS FGAVLGKTSP VQLIIMTLVE VTLFGINEYI ILNIVGAKDA
GGSMTIHTFG AYFGLIVSRV LYREDLEKSR QREGSVYHSD LFAMIGTIYL WMFWPSFNSA
VTAHGDDQHR TVMNTYYSLA ACTLATFGFS ALLNGEGKLD MVHIQNAALA GGVAVGTSGE
MMLTPFGAMI AGTLAGMISV LGYKYLTPVL DSKLKIQDTC GVHNLHGMPG ILGAIIGAIV
ALFATADIYG DGMGDVFPLI SDGSRTAKQQ SLYQFLALLV ALGFAIIGGT VVGFILKLPI
FGTPSDAECF EDAIYWEVPG GEGHQQLTVV INNEDPDTQA
