RHBG_TAKRU
ID RHBG_TAKRU Reviewed; 458 AA.
AC Q18PF6; Q7T3R6;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Ammonium transporter Rh type B;
DE AltName: Full=FRhbg;
DE AltName: Full=Rhesus blood group family type B glycoprotein;
DE Short=Rh family type B glycoprotein;
DE Short=Rh type B glycoprotein;
GN Name=rhbg;
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=16227429; DOI=10.1073/pnas.0507886102;
RA Huang C.-H., Peng J.;
RT "Evolutionary conservation and diversification of Rh family genes and
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AND
RP SUBCELLULAR LOCATION.
RX PubMed=17218543; DOI=10.1096/fj.06-6834com;
RA Nakada T., Westhoff C.M., Kato A., Hirose S.;
RT "Ammonia secretion from fish gill depends on a set of Rh glycoproteins.";
RL FASEB J. 21:1067-1074(2007).
CC -!- FUNCTION: Functions as an ammonia transporter. May play a role in the
CC elimination of ammonia in the gill. {ECO:0000269|PubMed:17218543}.
CC -!- SUBCELLULAR LOCATION: Apicolateral cell membrane
CC {ECO:0000269|PubMed:17218543}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17218543}. Cytoplasmic vesicle membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q18PF6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q18PF6-2; Sequence=VSP_024344;
CC -!- TISSUE SPECIFICITY: Specifically expressed in the gill by pavement
CC cells (at protein level). {ECO:0000269|PubMed:17218543}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM48577.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY116074; AAM48577.1; ALT_FRAME; mRNA.
DR EMBL; AB218980; BAE96342.1; -; mRNA.
DR RefSeq; NP_001027818.1; NM_001032646.1.
DR RefSeq; XP_011617146.1; XM_011618844.1. [Q18PF6-1]
DR RefSeq; XP_011617147.1; XM_011618845.1. [Q18PF6-2]
DR AlphaFoldDB; Q18PF6; -.
DR SMR; Q18PF6; -.
DR STRING; 31033.ENSTRUP00000012961; -.
DR GeneID; 445989; -.
DR KEGG; tru:445989; -.
DR CTD; 57127; -.
DR eggNOG; KOG3796; Eukaryota.
DR HOGENOM; CLU_021386_0_0_1; -.
DR InParanoid; Q18PF6; -.
DR OrthoDB; 910733at2759; -.
DR Proteomes; UP000005226; Unplaced.
DR GO; GO:0016327; C:apicolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
PE 1: Evidence at protein level;
KW Alternative splicing; Ammonia transport; Cell membrane;
KW Cytoplasmic vesicle; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..458
FT /note="Ammonium transporter Rh type B"
FT /id="PRO_0000283607"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..58
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..298
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 362..391
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..458
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 436..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 409..415
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16227429"
FT /id="VSP_024344"
SQ SEQUENCE 458 AA; 49664 MW; 342C46E6813B7A24 CRC64;
MTDAATNMRL KLPITCFILE IILIILFGTL VQYDYETDAK EWHNTSHQDY ENDFYFRYPS
FQDVHVMIFV GFGFLMTFLQ RYGFGSVGFN FLIAAFSLQW ATLMQGFFHG MHGGKIHIGV
ESMINADFCT GSVLISFGAV LGKTSPIQLL TMAIFEVTLF AVNEFILLSL LGTKDAGGSM
TIHTFGAYFG LMVTRILYRP NLDKSKHRNS SVYHSDLFAM IGTVYLWMFW PSFNSAITAH
GDDQHRTALN TYYSLAACTL ATYGMSAITS HDGKLDMVHI QNAALAGGVA VGTAGEMMLT
PFGSMIVGFM AGIISVLGFK FLSPILEDKL KIQDTCGIHN LHGMPGVLGA IVGAVTAALA
TTDVYGQGMA DVFPAVADGS VNATKQGGIQ ALSLAITLGI AVLGGLIVGF VLKLPVFGTP
PDTLCFEDSV YWEVPGSESP EEGELTSVKP EETEHLNS
