ID   RHBL1_MOUSE             Reviewed;         373 AA.
AC   Q8VC82;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Rhomboid-related protein 1;
DE            Short=RRP;
DE            EC=3.4.21.105;
DE   AltName: Full=Rhomboid-like protein 1;
GN   Name=Rhbdl1; Synonyms=Rhbdl;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Retina;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in regulated intramembrane proteolysis and
CC       the subsequent release of functional polypeptides from their membrane
CC       anchors. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad
CC         composed of serine and histidine that are contributed by different
CC         transmembrane domains.; EC=3.4.21.105;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the peptidase S54 family. {ECO:0000305}.
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DR   EMBL; BC021549; AAH21549.1; -; mRNA.
DR   CCDS; CCDS28534.1; -.
DR   RefSeq; NP_659065.1; NM_144816.1.
DR   AlphaFoldDB; Q8VC82; -.
DR   SMR; Q8VC82; -.
DR   STRING; 10090.ENSMUSP00000026831; -.
DR   BindingDB; Q8VC82; -.
DR   MEROPS; S54.005; -.
DR   iPTMnet; Q8VC82; -.
DR   PhosphoSitePlus; Q8VC82; -.
DR   SwissPalm; Q8VC82; -.
DR   PaxDb; Q8VC82; -.
DR   PRIDE; Q8VC82; -.
DR   ProteomicsDB; 255198; -.
DR   Antibodypedia; 22802; 31 antibodies from 13 providers.
DR   DNASU; 214951; -.
DR   Ensembl; ENSMUST00000026831; ENSMUSP00000026831; ENSMUSG00000025735.
DR   GeneID; 214951; -.
DR   KEGG; mmu:214951; -.
DR   UCSC; uc008bcg.1; mouse.
DR   CTD; 9028; -.
DR   MGI; MGI:2384891; Rhbdl1.
DR   VEuPathDB; HostDB:ENSMUSG00000025735; -.
DR   eggNOG; KOG2289; Eukaryota.
DR   GeneTree; ENSGT00940000160651; -.
DR   HOGENOM; CLU_048023_2_1_1; -.
DR   InParanoid; Q8VC82; -.
DR   OMA; VFMCYGV; -.
DR   OrthoDB; 1253228at2759; -.
DR   PhylomeDB; Q8VC82; -.
DR   TreeFam; TF313540; -.
DR   BioGRID-ORCS; 214951; 4 hits in 75 CRISPR screens.
DR   ChiTaRS; Rhbdl1; mouse.
DR   PRO; PR:Q8VC82; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q8VC82; protein.
DR   Bgee; ENSMUSG00000025735; Expressed in white adipose tissue and 61 other tissues.
DR   ExpressionAtlas; Q8VC82; baseline and differential.
DR   Genevisible; Q8VC82; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1540.10; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR   InterPro; IPR017213; Peptidase_S54_rhomboid_met.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   Pfam; PF01694; Rhomboid; 1.
DR   PIRSF; PIRSF037470; Rhomboid; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Membrane; Protease; Reference proteome; Serine protease;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..373
FT                   /note="Rhomboid-related protein 1"
FT                   /id="PRO_0000206174"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        247
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        312
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   373 AA;  41786 MW;  1F4E538B3A363D2A CRC64;
     MDRSSLLQLI QEQQLDPENT GFIGADTFAG LVHSHELPLD PTKLDMLVAL AQSNERGQVC
     YQELVDLISS KRSSSFKRAI ANGQRALPRD GLLDEPGLSV YKRFVRYVAY EILPCEVDRR
     WYFYRHRTCP PPVFMASVTL AQIIVFLCYG ARLNKWVLQT YHPEYMKSPL VYHPGHRARA
     WRFLTYMFMH VGLEQLGFNA LLQLMIGVPL EMVHGVLRIS LLYLAGVLAG SLTVSITDMR
     APVVGGSGGV YALCSAHLAN VVMNWAGMRC PYKLLRMVLA LVCMSSEVGR AVWLRFSPPL
     PASGPQPSFM AHLAGAVVGV SMGLTILRSY EERLRDQCGW WVVLLAYGTF LLFAIFWNVF
     AYDLLGADIP PPP