ID   RHBL1_RAT               Reviewed;         164 AA.
AC   O88779;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Rhomboid-related protein 1;
DE            Short=RRP;
DE            EC=3.4.21.105;
DE   AltName: Full=Rhomboid-like protein 1;
DE   Flags: Fragment;
GN   Name=Rhbdl1; Synonyms=Rhbdl;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestinal epithelium;
RX   PubMed=9662444; DOI=10.1016/s0014-5793(98)00622-x;
RA   Pascall J.C., Brown K.D.;
RT   "Characterization of a mammalian cDNA encoding a protein with high sequence
RT   similarity to the Drosophila regulatory protein Rhomboid.";
RL   FEBS Lett. 429:337-340(1998).
CC   -!- FUNCTION: May be involved in regulated intramembrane proteolysis and
CC       the subsequent release of functional polypeptides from their membrane
CC       anchors. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad
CC         composed of serine and histidine that are contributed by different
CC         transmembrane domains.; EC=3.4.21.105;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the peptidase S54 family. {ECO:0000305}.
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DR   EMBL; Y17258; CAA76716.1; -; mRNA.
DR   AlphaFoldDB; O88779; -.
DR   SMR; O88779; -.
DR   STRING; 10116.ENSRNOP00000026971; -.
DR   MEROPS; S54.005; -.
DR   PaxDb; O88779; -.
DR   UCSC; RGD:620699; rat.
DR   RGD; 620699; Rhbdl1.
DR   eggNOG; KOG2289; Eukaryota.
DR   InParanoid; O88779; -.
DR   PhylomeDB; O88779; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1540.10; -; 1.
DR   InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR   InterPro; IPR035952; Rhomboid-like_sf.
DR   Pfam; PF01694; Rhomboid; 1.
DR   SUPFAM; SSF144091; SSF144091; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Membrane; Protease; Reference proteome; Serine protease;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>164
FT                   /note="Rhomboid-related protein 1"
FT                   /id="PRO_0000206175"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        60
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        125
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         164
SQ   SEQUENCE   164 AA;  17662 MW;  CF62ACE3B6C99210 CRC64;
     FMHVGLEQLG FNALLQLMIG VPLEMVHGVL RISLLYLAGV LAGSLTVSIT DMRAPVVGGS
     GGVYALCSAH LANVVMNWAG MRCPYKLLRM VLALVCMSSE VGRAVWLRFS PPLPASGPQP
     SFMAHLAGAV VGVSMGLTIL RSYEERLRDQ CGWWVVLLAY GTFL