RHBT1_MOUSE
ID RHBT1_MOUSE Reviewed; 695 AA.
AC Q9DAK3; B2RPX3;
DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Rho-related BTB domain-containing protein 1;
GN Name=Rhobtb1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12426103; DOI=10.1016/s0378-1119(02)00980-0;
RA Ramos S., Khademi F., Somesh B.P., Rivero F.;
RT "Genomic organization and expression profile of the small GTPases of the
RT RhoBTB family in human and mouse.";
RL Gene 298:147-157(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 401-411, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
CC -!- TISSUE SPECIFICITY: Highest expression in heart and testis.
CC {ECO:0000269|PubMed:12426103}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC {ECO:0000305}.
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DR EMBL; AK005770; BAB24229.1; -; mRNA.
DR EMBL; CH466553; EDL32000.1; -; Genomic_DNA.
DR EMBL; CH466553; EDL32001.1; -; Genomic_DNA.
DR EMBL; CH466553; EDL32002.1; -; Genomic_DNA.
DR EMBL; CH466553; EDL32003.1; -; Genomic_DNA.
DR EMBL; CH466553; EDL32004.1; -; Genomic_DNA.
DR EMBL; BC137646; AAI37647.1; -; mRNA.
DR EMBL; BC137647; AAI37648.1; -; mRNA.
DR CCDS; CCDS35930.1; -.
DR RefSeq; NP_001074816.1; NM_001081347.1.
DR RefSeq; NP_001239565.1; NM_001252636.1.
DR RefSeq; NP_001239566.1; NM_001252637.1.
DR RefSeq; XP_006514111.1; XM_006514048.3.
DR RefSeq; XP_006514112.1; XM_006514049.3.
DR RefSeq; XP_006514114.1; XM_006514051.3.
DR RefSeq; XP_011241855.1; XM_011243553.2.
DR AlphaFoldDB; Q9DAK3; -.
DR SMR; Q9DAK3; -.
DR BioGRID; 213337; 5.
DR STRING; 10090.ENSMUSP00000020101; -.
DR iPTMnet; Q9DAK3; -.
DR PhosphoSitePlus; Q9DAK3; -.
DR MaxQB; Q9DAK3; -.
DR PaxDb; Q9DAK3; -.
DR PRIDE; Q9DAK3; -.
DR ProteomicsDB; 255327; -.
DR Antibodypedia; 14385; 187 antibodies from 27 providers.
DR Ensembl; ENSMUST00000020101; ENSMUSP00000020101; ENSMUSG00000019944.
DR Ensembl; ENSMUST00000067908; ENSMUSP00000065095; ENSMUSG00000019944.
DR Ensembl; ENSMUST00000164034; ENSMUSP00000132068; ENSMUSG00000019944.
DR GeneID; 69288; -.
DR KEGG; mmu:69288; -.
DR UCSC; uc007fmp.1; mouse.
DR CTD; 9886; -.
DR MGI; MGI:1916538; Rhobtb1.
DR VEuPathDB; HostDB:ENSMUSG00000019944; -.
DR eggNOG; KOG0393; Eukaryota.
DR GeneTree; ENSGT00940000159995; -.
DR HOGENOM; CLU_015517_0_0_1; -.
DR InParanoid; Q9DAK3; -.
DR OMA; VSKRTCP; -.
DR OrthoDB; 533443at2759; -.
DR PhylomeDB; Q9DAK3; -.
DR TreeFam; TF323347; -.
DR Reactome; R-MMU-9013422; RHOBTB1 GTPase cycle.
DR BioGRID-ORCS; 69288; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Rhobtb1; mouse.
DR PRO; PR:Q9DAK3; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9DAK3; protein.
DR Bgee; ENSMUSG00000019944; Expressed in myocardium of ventricle and 194 other tissues.
DR ExpressionAtlas; Q9DAK3; baseline and differential.
DR Genevisible; Q9DAK3; MM.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030865; P:cortical cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IBA:GO_Central.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.30.710.10; -; 2.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; PTHR24072; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00225; BTB; 2.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54695; SSF54695; 2.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS50097; BTB; 2.
DR PROSITE; PS51420; RHO; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; GTP-binding; Nucleotide-binding;
KW Reference proteome; Repeat.
FT CHAIN 1..695
FT /note="Rho-related BTB domain-containing protein 1"
FT /id="PRO_0000198961"
FT DOMAIN 266..426
FT /note="BTB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 484..551
FT /note="BTB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REGION 1..210
FT /note="Rho-like"
FT REGION 325..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 21..28
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 84..88
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 140..143
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT CONFLICT 636
FT /note="S -> Y (in Ref. 2; BAB24229)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 695 AA; 78819 MW; AA5F75C033004641 CRC64;
MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNTTL TQYQLLATHV PTVWAIDQYR
VCQEVLERSR DVVDEVSISL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLNHVKT
MWYQEIKHFC PRTPVVLVGC QLDLRYADLE AVNRARRPLA RPIKRGDILP PEKGREVAKE
LGIPYYETSV FDQFGIKDVF DNAIRAALIS RRHLQFWKSH LKKVQKPLLQ APFLPPKAPP
PVIKVPECPS AGTSDAACLL DNPLCADVLF VLHDEEHIFA HRIYLATSSS KFYDLFLMEC
EESPCWGGGA GEEVPCRDFQ GRTQSLGSAE EGKEGPQRTP QADPGASSGQ DLPESLALQM
EASGSEGHAL SGWSKGFVSM HREVRVNPIS KRVGPVTVVR LDPSMQSGPF RTLLRFLYSG
QLDEKEKDLL GLAQMAEVLE MFDLRMMVEN IMNKEAFMNQ EITKAFHVRK ANRIKECLSK
GTFSDVTFTL DDGAISAHKP LLICSCEWMA AMFGGSFVES ANREVHLPNI NKMSMQAVLE
YLYTKQLSPN LDLDPLELIA LANRFCLTHL VALVEQHAVQ ELTKAAVSGV SIDGEVLSYL
ELAQFHNANQ LAAWCLHHIC TNYNSVCSKF RKEIKSKSAD NQEYFERHRW PPVWYLKEED
HYQRVKRERE KEDLALNKHH SRRKWCFWHS SPAVA
