RHCG2_TAKRU
ID RHCG2_TAKRU Reviewed; 481 AA.
AC Q7T3R4;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Ammonium transporter Rh type C 2;
DE AltName: Full=FRhcg2;
DE AltName: Full=Rhesus blood group family type C glycoprotein 2;
DE Short=RHCG-2;
DE Short=Rh family type C glycoprotein 2;
DE Short=Rh type C glycoprotein 2;
GN Name=rhcg2;
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16227429; DOI=10.1073/pnas.0507886102;
RA Huang C.-H., Peng J.;
RT "Evolutionary conservation and diversification of Rh family genes and
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RX PubMed=17218543; DOI=10.1096/fj.06-6834com;
RA Nakada T., Westhoff C.M., Kato A., Hirose S.;
RT "Ammonia secretion from fish gill depends on a set of Rh glycoproteins.";
RL FASEB J. 21:1067-1074(2007).
CC -!- FUNCTION: Functions as an ammonia transporter. May play a role in the
CC elimination of ammonia in the gill. {ECO:0000269|PubMed:17218543}.
CC -!- SUBUNIT: Homotrimer.
CC -!- SUBCELLULAR LOCATION: Apicolateral cell membrane
CC {ECO:0000269|PubMed:17218543}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17218543}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in the gill by pavement
CC cells (at protein level). {ECO:0000269|PubMed:17218543}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000305}.
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DR EMBL; AY116076; AAM48579.1; -; mRNA.
DR EMBL; AB218982; BAE96344.1; -; mRNA.
DR RefSeq; NP_001027934.1; NM_001032762.1.
DR AlphaFoldDB; Q7T3R4; -.
DR SMR; Q7T3R4; -.
DR STRING; 31033.ENSTRUP00000046319; -.
DR GeneID; 445991; -.
DR KEGG; tru:445991; -.
DR CTD; 445991; -.
DR eggNOG; KOG3796; Eukaryota.
DR HOGENOM; CLU_021386_0_0_1; -.
DR InParanoid; Q7T3R4; -.
DR OrthoDB; 910733at2759; -.
DR Proteomes; UP000005226; Unplaced.
DR GO; GO:0016327; C:apicolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
PE 1: Evidence at protein level;
KW Ammonia transport; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..481
FT /note="Ammonium transporter Rh type C 2"
FT /id="PRO_0000283588"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..132
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..314
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..404
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 426..481
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 481 AA; 53225 MW; 880A6F25BB8954A3 CRC64;
MGNFFGRQRN AYVRVSLPAV CFVWQIAMII LFGVFIRYNE ESDAHWVEHK KTNNITSDIE
NDFYYRYPSF QDVHVMIFVG FGFLMTFLKR YSFGGVGFNF LIAAFGIQWA LLMQGWFHFL
DHSTGKIYIG VENLINADFC VAGSLIAYGA LLGKVSPVQL LVLTLFGVTL FAVEEYIILH
LLHCRDAGGS MVIHAFGGYY GLGISWVLYR PNLHQSKRLH GSVYHSDVFA MIGTLFLWMF
WPSFNSAITD HGDGQHRAAI NTYLGLASCV LTTVALSSMH DKRGRLDMVH IQNATLAGGV
AMGTAAEFMI SPYGALIVGF CCGIISTFGY LYVTPFLEKY LKLQDTCGVH NLHAVPGMLG
GFVGAIVAAA ATESVYSKEG LINTFNFEGK YADRSVGTQG GYQAAGTCVA VAFGLVGGAI
VGFILKFPIW GDPADDNCFD DEAYWEVPED EETIPPVLEY NNHMIHKHQD IAETNFSVEQ
S
