RHCG_BOVIN
ID RHCG_BOVIN Reviewed; 460 AA.
AC Q2T9S6; Q95M76;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Ammonium transporter Rh type C;
DE AltName: Full=Rhesus blood group family type C glycoprotein;
DE Short=Rh family type C glycoprotein;
DE Short=Rh type C glycoprotein;
GN Name=RHCG;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11358367; DOI=10.1006/bcmd.2000.0355;
RA Huang C.-H., Liu P.Z.;
RT "New insights into the Rh superfamily of genes and proteins in erythroid
RT cells and nonerythroid tissues.";
RL Blood Cells Mol. Dis. 27:90-101(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as an electroneutral and bidirectional ammonium
CC transporter. May regulate transepithelial ammonia secretion (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Note=Also detected at the basolateral
CC membrane and in subapical vesicles. {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY013260; AAK14650.1; -; mRNA.
DR EMBL; BC111288; AAI11289.1; -; mRNA.
DR RefSeq; NP_776597.1; NM_174172.2.
DR AlphaFoldDB; Q2T9S6; -.
DR SMR; Q2T9S6; -.
DR STRING; 9913.ENSBTAP00000007196; -.
DR PaxDb; Q2T9S6; -.
DR GeneID; 281456; -.
DR KEGG; bta:281456; -.
DR CTD; 51458; -.
DR eggNOG; KOG3796; Eukaryota.
DR HOGENOM; CLU_021386_0_0_1; -.
DR InParanoid; Q2T9S6; -.
DR OrthoDB; 910733at2759; -.
DR TreeFam; TF314450; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR GO; GO:0072488; P:ammonium transmembrane transport; ISS:UniProtKB.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
PE 2: Evidence at transcript level;
KW Ammonia transport; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..460
FT /note="Ammonium transporter Rh type C"
FT /id="PRO_0000283575"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..89
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..251
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..346
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 368..396
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..460
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 95
FT /note="Missing (in Ref. 1; AAK14650)"
FT /evidence="ECO:0000305"
FT CONFLICT 307
FT /note="S -> T (in Ref. 2; AAI11289)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 460 AA; 50834 MW; CFD2660D742CF94C CRC64;
MIWNTNLRWR LPVACLLLEV ALIALFGVFV RYDMDADPHW VQEKVIKNLS TDLENEFYYR
YPSFQDVHVM IFVGFGFLMT FLQRYGYSSV GFNFLLAAFG IQWALLMQGW LQSFDGRYIL
VDLENLINAD FCVGSVCVAF GAVLGKVSPV QLLIMTLFQV TLFSINEYIL LNLLEVKDSG
GSMTIHAFGA YFGLTVAWIL YRPNLHLSKE RQSSTYHSDL FAMIGTLFLW MYWPSFNSAI
SNHGDAQHRA AINTYCSLAA CVLTSVALSS ALHRKGKLDM VHIQNATLAG GVGLGTVAEL
MVLPFGSLII GFVCGIVSTL GFVYLTPFLE SRLHIQDTCG VHNLHGIPGI IGGIAGAVTA
SIANIDLYGE EGLAYAFGIE RSKLNWSPNM QGRFQAAGLF VSLAMALVGG VIVGVILRLP
FWGQAPDENC FEDAVYWEIP KEPKSTALRS EDSSIKPPEP
