ID   RHCG_XENLA              Reviewed;         473 AA.
AC   Q5U4V1;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Ammonium transporter Rh type C;
DE   AltName: Full=Rhesus blood group family type C glycoprotein;
DE            Short=Rh family type C glycoprotein;
DE            Short=Rh type C glycoprotein;
GN   Name=rhcg;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as an ammonia transporter. {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC084943; AAH84943.1; -; mRNA.
DR   AlphaFoldDB; Q5U4V1; -.
DR   SMR; Q5U4V1; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   InterPro; IPR002229; RhesusRHD.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   PRINTS; PR00342; RHESUSRHD.
PE   2: Evidence at transcript level;
KW   Ammonia transport; Cell membrane; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..473
FT                   /note="Ammonium transporter Rh type C"
FT                   /id="PRO_0000283592"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..61
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        83..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..125
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..151
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..179
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        241..251
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..285
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        307
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        329..343
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        365..396
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        418..473
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   473 AA;  52432 MW;  427BC3E1E08BBECF CRC64;
     MLRNSNMRWR LPLICFVWEI AMIVLFGIFV RYNDEADPHW PIFMKHENIT SDIENDFYFR
     YPSFQDVHVM IFVGFGFLMT FLQRYGFGSV AFNFLLAAFG IQWALLMQGW FHTFVNGKIL
     IGVESLINAD FCVGSVCIAF GGVLGKVSPV QIMLMTLFQV TLFAVNEWIL LNKLHVIDAG
     GSMTIHTFGA YFGLTVAWIL SRPKLKQNND KEGSTYISDL FSMIGTLFLW MYWPSFNSAI
     SYHGDAQHRA AINTYCSLAA CVLTTVAISS VVNKKGKLEM VHIQNATLAG GVAVGTAAEM
     MLTPYGSLIV GFICGIVSTL GFTYLSPILS NKLRLHDTCG IHNLHAIPGL IGGIVGAVTA
     ACATEGVYTA EGLKKMFHFE GEYADRTPSI QGIYQAAGIG VSLAFGIVGG TVVGCILKLP
     IWGDPSDENC FDDDVYWELR EEDEEEHLGA ANQYITHLPE NFKLPDRTEI SFK