RHCG_XENTR
ID RHCG_XENTR Reviewed; 467 AA.
AC Q6WRY0;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Ammonium transporter Rh type C;
DE AltName: Full=Rhesus blood group family type C glycoprotein;
DE Short=Rh family type C glycoprotein;
DE Short=Rh type C glycoprotein;
GN Name=rhcg;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16227429; DOI=10.1073/pnas.0507886102;
RA Huang C.-H., Peng J.;
RT "Evolutionary conservation and diversification of Rh family genes and
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005).
CC -!- FUNCTION: Functions as an ammonia transporter. {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000305}.
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DR EMBL; AY271818; AAQ02688.1; -; mRNA.
DR RefSeq; NP_001003661.1; NM_001003661.1.
DR AlphaFoldDB; Q6WRY0; -.
DR SMR; Q6WRY0; -.
DR STRING; 8364.ENSXETP00000063691; -.
DR PaxDb; Q6WRY0; -.
DR GeneID; 445260; -.
DR KEGG; xtr:445260; -.
DR CTD; 51458; -.
DR Xenbase; XB-GENE-949430; rhcg.
DR eggNOG; KOG3796; Eukaryota.
DR HOGENOM; CLU_021386_0_0_1; -.
DR InParanoid; Q6WRY0; -.
DR OMA; CCRGFWC; -.
DR OrthoDB; 910733at2759; -.
DR Reactome; R-XTR-444411; Rhesus glycoproteins mediate ammonium transport.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR GO; GO:0072488; P:ammonium transmembrane transport; ISS:UniProtKB.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
PE 2: Evidence at transcript level;
KW Ammonia transport; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..467
FT /note="Ammonium transporter Rh type C"
FT /id="PRO_0000283593"
FT TOPO_DOM 1..3
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..55
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..173
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..245
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..295
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 359..390
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 412..467
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 467 AA; 51560 MW; 2628CF5852BF3FAD CRC64;
MRLRLPVVCF LWEIAMIVLF GIFVRYNDEA DPHWSEFMKA QNITSDIQND YYFRYPSFQD
VHVMIFVGFG FLMTFLKRYG FGSVAFNFLL AAFGIQWAIL MQGWFHTFKN GKILIGVESL
INADFCVGSV CIAFGAILGK VSPVQIMVMT LFQVTLFAVN EWILLNLLHV NDAGGSMTIH
TFGAYFGLTV AWILNRPRLK QTNDKEGSVY VSDLFSMIGT LFLWMFWPSF NSAVSYHGDA
QHRAAINTYC SLAACVLTTV AISSVVNKKG KLEMVHIQNA TLAGGVAVGT AAEMMLTPYG
SLIVGFICGI VSTLGFTYCS PFLSNKLRLH DTCGIHNLHA MPGLIGGIVG AVTAACATEA
VYTADGLKKM FRFEGDYATR TPSMQGGYQA AGLCVSLAFG LVGGTVVGCI LKLPIWGDPS
DENCFDDEVY WELPEEDEEE HLGAANQYVT HLPENFKLPD RTEVAFK
