RHDF1_DANRE
ID RHDF1_DANRE Reviewed; 857 AA.
AC Q6GMF8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Inactive rhomboid protein 1;
DE Short=iRhom1;
DE AltName: Full=Rhomboid family member 1;
GN Name=rhbdf1; ORFNames=zgc:91984;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth
CC factor (EGF) receptor ligands and TNF, thereby plays a role in sleep,
CC cell survival, proliferation, migration and inflammation. Does not
CC exhibit any protease activity on its own.
CC {ECO:0000250|UniProtKB:Q96CC6}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96CC6};
CC Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized
CC in the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q96CC6}.
CC -!- SIMILARITY: Belongs to the peptidase S54 family. {ECO:0000305}.
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DR EMBL; BC074097; AAH74097.1; -; mRNA.
DR RefSeq; NP_001002228.1; NM_001002228.1.
DR AlphaFoldDB; Q6GMF8; -.
DR STRING; 7955.ENSDARP00000053094; -.
DR MEROPS; S54.952; -.
DR PaxDb; Q6GMF8; -.
DR Ensembl; ENSDART00000053095; ENSDARP00000053094; ENSDARG00000036541.
DR GeneID; 798402; -.
DR KEGG; dre:798402; -.
DR CTD; 798402; -.
DR ZFIN; ZDB-GENE-040704-75; rhbdf1a.
DR eggNOG; KOG2290; Eukaryota.
DR GeneTree; ENSGT00940000156278; -.
DR HOGENOM; CLU_011531_1_1_1; -.
DR InParanoid; Q6GMF8; -.
DR PhylomeDB; Q6GMF8; -.
DR TreeFam; TF312988; -.
DR PRO; PR:Q6GMF8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 3.
DR Bgee; ENSDARG00000036541; Expressed in granulocyte and 21 other tissues.
DR ExpressionAtlas; Q6GMF8; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR GO; GO:0008283; P:cell population proliferation; ISS:UniProtKB.
DR GO; GO:0050709; P:negative regulation of protein secretion; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0061136; P:regulation of proteasomal protein catabolic process; ISS:UniProtKB.
DR GO; GO:0050708; P:regulation of protein secretion; IBA:GO_Central.
DR Gene3D; 1.20.1540.10; -; 1.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR022241; Rhomboid_SP.
DR Pfam; PF01694; Rhomboid; 1.
DR Pfam; PF12595; Rhomboid_SP; 1.
DR SUPFAM; SSF144091; SSF144091; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Golgi apparatus;
KW Growth factor binding; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..857
FT /note="Inactive rhomboid protein 1"
FT /id="PRO_0000340111"
FT TOPO_DOM 1..413
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 435..661
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 662..682
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 683..693
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 694..714
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 715..716
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 717..737
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 738..748
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 749..769
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 770..774
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 775..795
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 796..805
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 806..826
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 827..857
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 283..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 585
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 857 AA; 97841 MW; A3C0611249B48132 CRC64;
MAELRRDSTS SLQRKKPPWL KLDIPTAHVS VDEVPAFVPP VKRQGFHRSA SMPVETSHFH
SPQRDIIDHR RAAFQRQSSI TQTIKRGTAD WFGVSKDGDA TQKWQRKSLR HCSLRYGKLK
PQVIREMELP SQDNISLTST ETPPPLYVPS SQHGMQKIVD PLARGRAFRM VEEVDGYSVP
QTPITPGAAS ICSFNSSRSG LNRIPRRRKR ESVAKMSFRA AAALVKGRSL REGTLRRAHR
RSFTPASFIE EDVVDFPDEL DTSFFARDIM MHEEMSTFHD EVFESPSDST MKDVDSKQLD
ESELTGSALD KSELEKSHLM LPLERGWRKV KEKTPAPPKI RLKQEVVSVN GQRRGQRIGL
PVKKLFAREK RPYGLGMVGK LTNRTYRKRI DSYVKKQIED MDDHRPFFTY WITFVHILIT
ILAVCIYGIA PVGFSQHETV DSVLRNKGVY ENVKFVQQEN FWIGPSSEAL IHLGAKFSPC
MRRDNQVHEL IKKKQELERN SACCVRNDRS GCLQTSEEEC SSTLAVWVKW PQHPSVPQLD
GVARQHGSVC HQDPRTCTEP ASVSPHEWPD DITKWPICTK YNSGNHTNLP HIDCTITGRP
CCIGTKGRCE ITSREYCDFM KGYFHEEATL CSQVHCMDDV CGLLPFLNPE VPDQFYRLWL
SLFLHAGILH CLVSVCFQMT ILRDLEKLAG WLRISIIYIL SGITGNLASA IFLPYRAEVG
PAGSQFGILA CLFVELIQSW QILAQPWRAF TKLLCVVLFL FAFGLLPWID NFAHISGFIS
GFFLSFAFLP YISFGRLDMY RKRCQIIIFL VVFLGLFAGL VVLFYVHPIK CEWCELLTCI
PFTDKFCEKY DLNAHLH
