RHD_MOUSE
ID RHD_MOUSE Reviewed; 418 AA.
AC Q8CF94; O88296; O88297; Q9QUM6; Q9QX04;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Blood group Rh(D) polypeptide;
DE AltName: Full=Erythrocyte membrane glycoprotein Rh30;
DE AltName: CD_antigen=CD240D;
GN Name=Rhd; Synonyms=Rh30, Rhced;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BFM-2MsfB6C3FI, and C57BL-10SnJ; TISSUE=Bone marrow;
RX PubMed=9705835; DOI=10.1006/bbrc.1998.9074;
RA Kitano T., Sumiyama K., Shiroishi T., Saitou N.;
RT "Conserved evolution of the Rh50 gene compared to its homologous Rh blood
RT group gene.";
RL Biochem. Biophys. Res. Commun. 249:78-85(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Spleen;
RX PubMed=10329015; DOI=10.1006/geno.1999.5783;
RA Westhoff C.M., Schultze A., From A., Wylie D.E., Silberstein L.E.;
RT "Characterization of the mouse Rh blood group gene.";
RL Genomics 57:451-454(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=9929383; DOI=10.1007/pl00006453;
RA Matassi G., Cherif-Zahar B., Pesole G., Raynal V., Cartron J.-P.;
RT "The members of the RH gene family (RH50 and RH30) followed different
RT evolutionary pathways.";
RL J. Mol. Evol. 48:151-159(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12459264; DOI=10.1016/s0378-1119(02)01054-5;
RA Kumada M., Iwamoto S., Kamesaki T., Okuda H., Kajii E.;
RT "Entire sequence of a mouse chromosomal segment containing the gene Rhced
RT and a comparative analysis of the homologous human sequence.";
RL Gene 299:165-172(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16227429; DOI=10.1073/pnas.0507886102;
RA Huang C.-H., Peng J.;
RT "Evolutionary conservation and diversification of Rh family genes and
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be part of an oligomeric complex which is likely to have
CC a transport or channel function in the erythrocyte membrane.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q02161};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q02161}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000305}.
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DR EMBL; AB015189; BAA32438.1; -; mRNA.
DR EMBL; AB015190; BAA32439.1; -; mRNA.
DR EMBL; AF069311; AAC64038.1; -; mRNA.
DR EMBL; AF047827; AAD13391.1; -; mRNA.
DR EMBL; AB076248; BAC21151.1; -; Genomic_DNA.
DR EMBL; AF057524; AAC25123.1; -; mRNA.
DR EMBL; AK079335; BAC37610.1; -; mRNA.
DR EMBL; AK171641; BAE42581.1; -; mRNA.
DR EMBL; AL611963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466552; EDL29999.1; -; Genomic_DNA.
DR EMBL; BC145805; AAI45806.1; -; mRNA.
DR CCDS; CCDS18778.1; -.
DR RefSeq; NP_035400.3; NM_011270.3.
DR AlphaFoldDB; Q8CF94; -.
DR SMR; Q8CF94; -.
DR STRING; 10090.ENSMUSP00000030627; -.
DR MaxQB; Q8CF94; -.
DR PaxDb; Q8CF94; -.
DR PRIDE; Q8CF94; -.
DR ProteomicsDB; 255199; -.
DR DNASU; 19746; -.
DR GeneID; 19746; -.
DR KEGG; mmu:19746; -.
DR CTD; 6007; -.
DR MGI; MGI:1202882; Rhd.
DR eggNOG; KOG3796; Eukaryota.
DR InParanoid; Q8CF94; -.
DR OrthoDB; 910733at2759; -.
DR PhylomeDB; Q8CF94; -.
DR TreeFam; TF314450; -.
DR BioGRID-ORCS; 19746; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Rhd; mouse.
DR PRO; PR:Q8CF94; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8CF94; protein.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR GO; GO:0072488; P:ammonium transmembrane transport; IMP:MGI.
DR GO; GO:0048821; P:erythrocyte development; IMP:MGI.
DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:MGI.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
PE 1: Evidence at protein level;
KW Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..418
FT /note="Blood group Rh(D) polypeptide"
FT /id="PRO_0000383326"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 398
FT /note="H -> R"
FT CONFLICT 3
FT /note="S -> C (in Ref. 5; AAC25123)"
FT /evidence="ECO:0000305"
FT CONFLICT 19
FT /note="E -> V (in Ref. 1; BAA32438)"
FT /evidence="ECO:0000305"
FT CONFLICT 20
FT /note="L -> V (in Ref. 5; AAC25123)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="T -> I (in Ref. 1; BAA32439)"
FT /evidence="ECO:0000305"
FT CONFLICT 25
FT /note="S -> I (in Ref. 1; BAA32438)"
FT /evidence="ECO:0000305"
FT CONFLICT 28
FT /note="F -> S (in Ref. 1; BAA32438)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="R -> K (in Ref. 1; BAA32438)"
FT /evidence="ECO:0000305"
FT CONFLICT 45
FT /note="A -> E (in Ref. 1; BAA32438)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="V -> M (in Ref. 1; BAA32438)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="V -> M (in Ref. 5; AAC25123)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 418 AA; 45877 MW; 76AAC777FA5BF633 CRC64;
MGSKYPRSLR CCLPLWALEL QTAFSLLFCF FIPHDTAQVD HRFMASYQVL RNLTLMAALG
FGFLSSSFRR HSWSSVAFNL FMLALGVQGT ILLDHFLGQV LQWNKINNLS SIQIATMSTL
PVLISAGAVL GKVNLVQLTV MVLMEAMAFG AIRFADEKVF KMTEHIIMMH GHVFGAYFGL
TVAWWLSRSL PRRVGENAQT EKVQMATSSS LFAMLGTLFL WIFWPAINSA LLEGTKKRNA
VFNTYYALAV SAVTATSMSA LSHPQGKINM VHIHNAVLAG GVAVGAPGCL ISSPWISMVL
GLIAGLISIW GAKCPRACLN HMLQNSSGIH YTFGLPGLLG ALTYYCLQIV TEPKSSDLWI
ITQTVTHIGA LSFAVAMGMV TGLLTGCLLS VRVWRAPHAA KYFDDQTFWE FPHLAVGF
