ID   RHD_RAT                 Reviewed;         422 AA.
AC   O88298;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Blood group Rh(D) polypeptide;
DE   AltName: Full=Erythrocyte membrane glycoprotein Rh30;
DE   AltName: CD_antigen=CD240D;
GN   Name=Rhd; Synonyms=Rh30, Rhced;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=9705835; DOI=10.1006/bbrc.1998.9074;
RA   Kitano T., Sumiyama K., Shiroishi T., Saitou N.;
RT   "Conserved evolution of the Rh50 gene compared to its homologous Rh blood
RT   group gene.";
RL   Biochem. Biophys. Res. Commun. 249:78-85(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   PubMed=16227429; DOI=10.1073/pnas.0507886102;
RA   Huang C.-H., Peng J.;
RT   "Evolutionary conservation and diversification of Rh family genes and
RT   proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be part of an oligomeric complex which is likely to have
CC       a transport or channel function in the erythrocyte membrane.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q02161};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q02161}.
CC   -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB015191; BAA32440.1; -; mRNA.
DR   EMBL; AF531096; AAQ10013.1; -; mRNA.
DR   EMBL; BC127471; AAI27472.1; -; mRNA.
DR   RefSeq; NP_071950.1; NM_022505.2.
DR   AlphaFoldDB; O88298; -.
DR   SMR; O88298; -.
DR   STRING; 10116.ENSRNOP00000023187; -.
DR   PaxDb; O88298; -.
DR   Ensembl; ENSRNOT00000023187; ENSRNOP00000023187; ENSRNOG00000017130.
DR   GeneID; 60414; -.
DR   KEGG; rno:60414; -.
DR   CTD; 6007; -.
DR   RGD; 620451; Rhd.
DR   eggNOG; KOG3796; Eukaryota.
DR   GeneTree; ENSGT00950000182844; -.
DR   HOGENOM; CLU_021386_1_0_1; -.
DR   InParanoid; O88298; -.
DR   OMA; SSPWIAM; -.
DR   OrthoDB; 910733at2759; -.
DR   PhylomeDB; O88298; -.
DR   TreeFam; TF314450; -.
DR   PRO; PR:O88298; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000017130; Expressed in spleen and 7 other tissues.
DR   Genevisible; O88298; RN.
DR   GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR   GO; GO:0072488; P:ammonium transmembrane transport; ISO:RGD.
DR   GO; GO:0048821; P:erythrocyte development; ISO:RGD.
DR   GO; GO:0060586; P:multicellular organismal iron ion homeostasis; ISO:RGD.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   InterPro; IPR002229; RhesusRHD.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   PRINTS; PR00342; RHESUSRHD.
PE   2: Evidence at transcript level;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..422
FT                   /note="Blood group Rh(D) polypeptide"
FT                   /id="PRO_0000383327"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   422 AA;  46583 MW;  3039E4C72464E66A CRC64;
     MGSKYPRSLR CCLPLWAFGL QVTFILLFYF LIGQDPIQAD HKFMAIYQVI QDLTLVAALG
     FGFLSSSFRR HGWSSVAFSF FMLALGVQGT ILLDYFLNWV LDWNMIKNPF SPFLSIQRAT
     ISTLPLLISA GAVLGKVNLV QLAVMVLVEA MTFGAIRVAD KKVFRIEDHI IMMYGHVFGA
     YFGLTVAWWL SKSLPRRRHE NAQTEKVQMT TSSSLFAMLG TLFLWIFWPS INSALLEGTK
     KKNAVFNTYY ALAVSTVTAT SMSALSHPKG KINMVHIHNA VLAGGVAVGA PSCLISSPWI
     AMVLGLTAGL ISIWGAKCPQ VCLSDLLLNP SGIHYTFGLP GLLGALTYYC LHIIAESRPS
     NLWIVTQTIT DVGALSFAMA MGMVTGLLTG CLLSVKVWRA PHAVKYFDDQ AFWEFPHLAV
     EF