ID   RHG06_TAKRU             Reviewed;          53 AA.
AC   O57414;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Rho GTPase-activating protein 6;
DE   AltName: Full=Rho-type GTPase-activating protein 6;
DE   AltName: Full=Rho-type GTPase-activating protein RhoGAPX-1;
DE   Flags: Fragment;
GN   Name=arhgap6;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9417914; DOI=10.1006/geno.1997.5040;
RA   Schaefer L., Prakash S.K., Zoghbi H.Y.;
RT   "Cloning and characterization of a novel rho-type GTPase-activating protein
RT   gene (ARHGAP6) from the critical region for microphthalmia with linear skin
RT   defects.";
RL   Genomics 46:268-277(1997).
CC   -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC       to an inactive GDP-bound state. Could regulate the interactions of
CC       signaling molecules with the actin cytoskeleton. Promotes continuous
CC       elongation of cytoplasmic processes during cell motility and
CC       simultaneous retraction of the cell body changing the cell morphology
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF012274; AAC60333.1; -; Genomic_DNA.
DR   AlphaFoldDB; O57414; -.
DR   STRING; 31033.ENSTRUP00000032133; -.
DR   eggNOG; KOG2710; Eukaryota.
DR   HOGENOM; CLU_012874_0_0_1; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   GO; GO:0043087; P:regulation of GTPase activity; IEA:InterPro.
DR   InterPro; IPR030772; RhoGAP6.
DR   InterPro; IPR037863; RHOGAP6/36.
DR   PANTHER; PTHR12635; PTHR12635; 1.
DR   PANTHER; PTHR12635:SF6; PTHR12635:SF6; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           <1..>53
FT                   /note="Rho GTPase-activating protein 6"
FT                   /id="PRO_0000056706"
FT   NON_TER         1
FT   NON_TER         53
SQ   SEQUENCE   53 AA;  6050 MW;  79AF766A6CCE2E97 CRC64;
     GDFTWNSLSG RSVRLAPVDI QSLSELERAR LQEVAFTRLH QDYDLGCQIT MPK