ID   RHG15_BOVIN             Reviewed;         471 AA.
AC   A4IF90;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Rho GTPase-activating protein 15;
DE   AltName: Full=ArhGAP15;
DE   AltName: Full=Rho-type GTPase-activating protein 15;
GN   Name=ARHGAP15;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC       to an inactive GDP-bound state. Has activity toward RAC1.
CC       Overexpression results in an increase in actin stress fibers and cell
CC       contraction (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- DOMAIN: The PH domain is required for localization to the membrane.
CC       {ECO:0000250}.
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DR   EMBL; BC134460; AAI34461.1; -; mRNA.
DR   RefSeq; NP_001098473.1; NM_001105003.2.
DR   AlphaFoldDB; A4IF90; -.
DR   SMR; A4IF90; -.
DR   STRING; 9913.ENSBTAP00000053462; -.
DR   PaxDb; A4IF90; -.
DR   PRIDE; A4IF90; -.
DR   Ensembl; ENSBTAT00000061453; ENSBTAP00000053462; ENSBTAG00000032289.
DR   GeneID; 616246; -.
DR   KEGG; bta:616246; -.
DR   CTD; 55843; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032289; -.
DR   VGNC; VGNC:26076; ARHGAP15.
DR   eggNOG; KOG1450; Eukaryota.
DR   eggNOG; KOG1453; Eukaryota.
DR   GeneTree; ENSGT00950000182860; -.
DR   HOGENOM; CLU_015883_1_0_1; -.
DR   InParanoid; A4IF90; -.
DR   OMA; DHNQWED; -.
DR   OrthoDB; 1300981at2759; -.
DR   TreeFam; TF329345; -.
DR   Reactome; R-BTA-9013423; RAC3 GTPase cycle.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000032289; Expressed in neutrophil and 99 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTPase activation; Membrane; Phosphoprotein; Reference proteome.
FT   CHAIN           1..471
FT                   /note="Rho GTPase-activating protein 15"
FT                   /id="PRO_0000317573"
FT   DOMAIN          79..189
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          281..470
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         43
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q53QZ3"
FT   MOD_RES         196
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q811M1"
FT   MOD_RES         199
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AYC5"
FT   MOD_RES         243
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AYC5"
SQ   SEQUENCE   471 AA;  54110 MW;  C9247EEA8902E57D CRC64;
     MQKSTNSDIP VETLNPTRQG TGAVQMRIKN ANSHHDRLSQ SKSMILTEVG KVTEPISRHR
     RNHSQHILKD VIPPLEQLMV EKEGYLQKAK IADGGKKLRK NWTTSWIVLS SRKIEFYKES
     KQQALSNMKT GNKPESVDLC GAHIEWAKEK SSRKNVFQIT TLSGNEFLLQ SDIDFIILDW
     FHAIKNAIDR LPKDPSSHSR NLELFKIQRS SSTELLSHYD SDTKEQKPEH RKSLMFRLHH
     SASDTSDKNR VKSRLKKFIT RRPSLKTLQE KGLIKDQIFG SHLHTLCERE KSTVPRFVKQ
     CIEAVEKRGL DVDGIYRVSG NLATIQKLRF IVNQEEKLNL DDSQWEDIHV VTGALKMFFR
     DLPEPLFPYS FFEQFVEAIK KQDNNTRIEA IKSLVQKLPP PNRDTMKVLF GHLTKIVARA
     SKNLMSTHSL GIVFGPTLLR AEDESGNMAV HMVYQNQIAE LMLSAYDQIF S