ID   RHG15_CHICK             Reviewed;         475 AA.
AC   Q5ZMM3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Rho GTPase-activating protein 15;
DE   AltName: Full=ArhGAP15;
DE   AltName: Full=Rho-type GTPase-activating protein 15;
GN   Name=ARHGAP15; ORFNames=RCJMB04_1j23;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC       to an inactive GDP-bound state. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
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DR   EMBL; AJ719361; CAG31020.1; -; mRNA.
DR   RefSeq; NP_001008476.1; NM_001008476.1.
DR   AlphaFoldDB; Q5ZMM3; -.
DR   SMR; Q5ZMM3; -.
DR   STRING; 9031.ENSGALP00000037032; -.
DR   PaxDb; Q5ZMM3; -.
DR   PRIDE; Q5ZMM3; -.
DR   Ensembl; ENSGALT00000037826; ENSGALP00000037032; ENSGALG00000012421.
DR   Ensembl; ENSGALT00000064878; ENSGALP00000048638; ENSGALG00000012421.
DR   Ensembl; ENSGALT00000075184; ENSGALP00000054199; ENSGALG00000012421.
DR   GeneID; 424303; -.
DR   KEGG; gga:424303; -.
DR   CTD; 55843; -.
DR   VEuPathDB; HostDB:geneid_424303; -.
DR   eggNOG; KOG1450; Eukaryota.
DR   eggNOG; KOG4269; Eukaryota.
DR   GeneTree; ENSGT00950000182860; -.
DR   HOGENOM; CLU_015883_1_0_1; -.
DR   InParanoid; Q5ZMM3; -.
DR   OMA; DHNQWED; -.
DR   OrthoDB; 1300981at2759; -.
DR   PhylomeDB; Q5ZMM3; -.
DR   TreeFam; TF329345; -.
DR   Reactome; R-GGA-9013149; RAC1 GTPase cycle.
DR   Reactome; R-GGA-9013423; RAC3 GTPase cycle.
DR   PRO; PR:Q5ZMM3; -.
DR   Proteomes; UP000000539; Chromosome 7.
DR   Bgee; ENSGALG00000012421; Expressed in granulocyte and 10 other tissues.
DR   ExpressionAtlas; Q5ZMM3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTPase activation; Membrane; Reference proteome.
FT   CHAIN           1..475
FT                   /note="Rho GTPase-activating protein 15"
FT                   /id="PRO_0000317577"
FT   DOMAIN          80..190
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          281..470
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  54610 MW;  4797AB88070D333F CRC64;
     MERSTTSDTA SEKPNPSHST GAVQMRIKNA NSHHDRLSQS KSMILSDNVK VLEPINRHRR
     NHSQHNLTLA DIISTPDHTV VEKEGYLLKA KIADGGKKLR KNWSTSWIVL TSRKMEFYKE
     SKQPALANLK PGYKPECVDL CGAHIEWTPE KSSRKNVFQI TTVSGNEFLL QSDIDFLILD
     WFHAIKNAID RLPKERSCTS RNLEFKLRRS SSTELLNSLD TESKESKPEH RKSLIFRLNY
     SASDSNDRSR VKSRLKKFIS RRPSLKTLQE KGLIKDQIFG SHLHLVCEHE NSTVPQFVRQ
     CIKAVERRGL EVDGIYRVSG NLATIQKLRF VVNQEEKLNL DDSQWEDIHV VTGALKMFFR
     ELPEPLFPYC FFEQFVEAIK IQDNATRIKA VKTLVKKLPR PNYDTMKVLF EHLKKIAAKE
     SVNLMSTQSL GIVFGPTLLR PEKETGNMAV HMLYQNQIVE LMLSEYSKIF GSEED