ID   RHG19_XENLA             Reviewed;         507 AA.
AC   Q6INE5;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Rho GTPase-activating protein 19;
DE   AltName: Full=Rho-type GTPase-activating protein 19;
GN   Name=arhgap19;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC       to an inactive GDP-bound state. {ECO:0000250}.
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DR   EMBL; BC072338; AAH72338.1; -; mRNA.
DR   RefSeq; NP_001085418.1; NM_001091949.1.
DR   AlphaFoldDB; Q6INE5; -.
DR   SMR; Q6INE5; -.
DR   DNASU; 443844; -.
DR   GeneID; 443844; -.
DR   KEGG; xla:443844; -.
DR   CTD; 443844; -.
DR   Xenbase; XB-GENE-6251735; arhgap19.L.
DR   OrthoDB; 878646at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 443844; Expressed in blastula and 12 other tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..507
FT                   /note="Rho GTPase-activating protein 19"
FT                   /id="PRO_0000280468"
FT   DOMAIN          112..305
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          344..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..418
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  57404 MW;  DB63E478AF350326 CRC64;
     MAATEDGGEV DRGISGDALC RIVICNDASL RSQPVIYNPD FFVEKLRHEN PEVFTELVVS
     NLTRLIDLPG TELAQLMGEV DPKLPGHNGA ASSFFRSLNF LKRKEKGIVF GAPLTEEGIA
     QIYQLIDYLH KNLRTEGLFR IPGNSIRQQN LKDLLNSGMD IDVESGEFHP NDVATLLKMF
     LGELPEPLLT HRHYIAHLKI ANLMLFDAKG NRTGVPDKER QIEALQLLFL LLPSPNRNLL
     KLLLDLLYQT ARKQDRNKMS AHNLALMFAP HIIWPKNLTA NDLQEHLIKL NNGVTFMIKH
     SQKLFKAPPY IREYARLHFS GSRTPASKDD LDLLPTRSPS EFHFLKHSKR SRLGSSPSSS
     TSLQEQTQQH TEEALKELFR HVHNMPDSAK KKRLIRQFNK NTPRTPVSDT QVPNGKKHVR
     SRTFSGMIKR KVLGSQMASE KKSRTITPQS ADGSEYAKEN LKYVSVDSPA VYFTRAKLKL
     SEDLQIRKEA SSKSKKSHHK STQETSI