RHG26_XENTR
ID RHG26_XENTR Reviewed; 759 AA.
AC B5DFQ4; B1H128;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Rho GTPase-activating protein 26;
DE AltName: Full=Rho-type GTPase-activating protein 26;
GN Name=arhgap26;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=N6; TISSUE=Embryo, and Intestine;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase-activating protein for rhoa and cdc42. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}.
CC Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with actin
CC stress fibers and cortical actin structures. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B5DFQ4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B5DFQ4-2; Sequence=VSP_035910, VSP_035911;
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DR EMBL; BC160445; AAI60445.1; -; mRNA.
DR EMBL; BC169150; AAI69150.1; -; mRNA.
DR RefSeq; NP_001120245.2; NM_001126773.2. [B5DFQ4-1]
DR AlphaFoldDB; B5DFQ4; -.
DR SMR; B5DFQ4; -.
DR Ensembl; ENSXETT00000003971; ENSXETP00000003971; ENSXETG00000001880.
DR GeneID; 100145296; -.
DR KEGG; xtr:100145296; -.
DR CTD; 23092; -.
DR Xenbase; XB-GENE-1011980; arhgap26.
DR eggNOG; KOG1451; Eukaryota.
DR HOGENOM; CLU_011532_2_0_1; -.
DR InParanoid; B5DFQ4; -.
DR OrthoDB; 693048at2759; -.
DR Reactome; R-XTR-9013026; RHOB GTPase cycle.
DR Reactome; R-XTR-9013106; RHOC GTPase cycle.
DR Reactome; R-XTR-9013148; CDC42 GTPase cycle.
DR Reactome; R-XTR-9013149; RAC1 GTPase cycle.
DR Reactome; R-XTR-9013404; RAC2 GTPase cycle.
DR Reactome; R-XTR-9013406; RHOQ GTPase cycle.
DR Reactome; R-XTR-9013409; RHOJ GTPase cycle.
DR Reactome; R-XTR-9013423; RAC3 GTPase cycle.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000001880; Expressed in 4-cell stage embryo and 13 other tissues.
DR ExpressionAtlas; B5DFQ4; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07636; BAR_GRAF; 1.
DR CDD; cd12064; SH3_GRAF; 1.
DR Gene3D; 1.10.555.10; -; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR030061; GRAF.
DR InterPro; IPR035483; GRAF_BAR.
DR InterPro; IPR035481; GRAF_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552:SF4; PTHR12552:SF4; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell junction; Cytoplasm; Cytoskeleton;
KW GTPase activation; Reference proteome; SH3 domain.
FT CHAIN 1..759
FT /note="Rho GTPase-activating protein 26"
FT /id="PRO_0000355555"
FT DOMAIN 265..369
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 383..568
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT DOMAIN 701..759
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 578..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..683
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 513
FT /note="N -> K (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035910"
FT VAR_SEQ 514..759
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_035911"
SQ SEQUENCE 759 AA; 86493 MW; 82B510C0CC10C40F CRC64;
MGLPPLEFSD CYLDSPQFRE RLKSHEIELD KTNKFIKELI KDGKSLVAAH KNLSCAKRKF
AGSLNEFKFR CIGDAETDDE ICIARSLQEF AAVLGNLEDE RIRMIDNSGE VLISPLEKFR
KEQVGAAKEV KKKYDKESEK YCAMLEKHMN LSSKKKEVLL HEADVQLDQM RQHFYEVSLE
YVLKVHEVQE RKMFEFVEPL LAFLQGLFTF YHHGYELAKD FSDFKTQLSI SIQNTRDRFE
GTRSEVESLM KKMKENPHEH LALSPYTMEG YLYVQEKRHF GTSWVKHYCT YQRETKQMTM
VPFDQKSGGK VGEEEIIHLK SCIRRKTESI EKRFCFDVEG VDRPTVLTMQ ALSEEDRKLW
MEAMDGREPV YNSNKDSQSE GTAQLDNIGF SIIRKCIQAV ETRGINEQGL YRIVGVNSRV
QKLLNFLMDP KISPETETEI PSEWEIKTIT SSLKTYLRML PGPLMTYQFQ RSFIKAAKLE
NQESRIKEIH CLIHRLPEKN RQMLNLLMTH LANVAAHHKQ NLMTVANLGI VFGPTLLRPQ
EETVAAIMDI KFQNIVVEII IENYEKMFST VPEMPQTNSQ LHLSRKRSSD SKPPSCSERP
LTLFHTTHNT EKEEKRNSVN SSAESVSSSN ANSSANSTCT QCSNMNNLNA SDPDLDVAKA
SRPNSLSLNP SPTSPPTCPM FSAPSSPMPT SSTSSDSSPV SVPRKAKALY ACKAEHDSEL
SFSAGTVFDN VYPSQEPGWL EGILNGKTGL IPENYVEFL
