ID   RHG36_AILME             Reviewed;         547 AA.
AC   D2H9U0;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Rho GTPase-activating protein 36;
DE   Flags: Precursor;
GN   Name=ARHGAP36; ORFNames=PANDA_007122;
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
CC   -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC       to an inactive GDP-bound state. {ECO:0000250}.
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DR   EMBL; GL192610; EFB26848.1; -; Genomic_DNA.
DR   RefSeq; XP_002918650.1; XM_002918604.3.
DR   AlphaFoldDB; D2H9U0; -.
DR   SMR; D2H9U0; -.
DR   Ensembl; ENSAMET00000049380; ENSAMEP00000026208; ENSAMEG00000014800.
DR   GeneID; 100477893; -.
DR   KEGG; aml:100477893; -.
DR   CTD; 158763; -.
DR   GeneTree; ENSGT00940000153904; -.
DR   InParanoid; D2H9U0; -.
DR   OrthoDB; 419555at2759; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04376; RhoGAP_ARHGAP6; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR041852; ARHGAP6_RhoGAP.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037863; RHOGAP6/36.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR12635; PTHR12635; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Reference proteome; Signal.
FT   SIGNAL          1..40
FT                   /evidence="ECO:0000255"
FT   CHAIN           41..547
FT                   /note="Rho GTPase-activating protein 36"
FT                   /id="PRO_0000394286"
FT   DOMAIN          226..426
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          493..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..520
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  61850 MW;  E348BA68FD0D4FE7 CRC64;
     MGGCNPFLKA ARTLCPRIMP PLLFLSAFIF LVNVLGGAPG HNPDRRTKMI SIHSLSELER
     LKLQETAYHE LVARHFLSEF KPDRALPIDR PNTFEKWFLI LRGQQRAVSL KTFGIRLEEV
     LVNELTRRKH LELTAAMQIE ESTGQASGRR RGNVVQRLFG RIRRFFSSRR DEPSLPREFT
     RRGRRGAVSV DSLAELEDGA LLLQTLQLSK ISFPIGQRLL GSKRKMSLNP IAKQIPQVVE
     ACCSFIEKHG LSAVGIFTLE YSEERVRELR EEFDQGLDVV LDDTQNVHDV AALLKEFFRD
     MKDSLLPDDL YMSFLLTATL KPQDQLSALQ LLVYLMPPCH SDTLERLLKA LHKITENCED
     SIGIDGQLVS GNRMTSTNLA LVFGSALLKK GRFAKRESRK TRLGIDHYVA SVNVVRAMID
     NWDILFQVPP HIQKQVAKRV WKSSPEALDF IRRRNLRKIQ SARIKMEEDA LLSDPVENSA
     EAWAAVLAQS KPFDEGSSEE PAVPPGTAHS HDDEEGAGNP PIPEQDRPLL RVPREKQAKT
     GIGYFFP