ID   RHG36_BOVIN             Reviewed;         530 AA.
AC   A7MB27;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Rho GTPase-activating protein 36;
DE   Flags: Precursor;
GN   Name=ARHGAP36;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC       to an inactive GDP-bound state. {ECO:0000250}.
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DR   EMBL; BC151300; AAI51301.1; -; mRNA.
DR   RefSeq; NP_001095458.1; NM_001101988.2.
DR   AlphaFoldDB; A7MB27; -.
DR   SMR; A7MB27; -.
DR   STRING; 9913.ENSBTAP00000028237; -.
DR   PaxDb; A7MB27; -.
DR   Ensembl; ENSBTAT00000028237; ENSBTAP00000028237; ENSBTAG00000021189.
DR   GeneID; 514137; -.
DR   KEGG; bta:514137; -.
DR   CTD; 158763; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021189; -.
DR   VGNC; VGNC:26093; ARHGAP36.
DR   eggNOG; KOG2710; Eukaryota.
DR   GeneTree; ENSGT00940000153904; -.
DR   HOGENOM; CLU_012874_1_1_1; -.
DR   InParanoid; A7MB27; -.
DR   OMA; NTFEKWF; -.
DR   OrthoDB; 419555at2759; -.
DR   TreeFam; TF316710; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000021189; Expressed in spermatocyte and 39 other tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04376; RhoGAP_ARHGAP6; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR041852; ARHGAP6_RhoGAP.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037863; RHOGAP6/36.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR12635; PTHR12635; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..530
FT                   /note="Rho GTPase-activating protein 36"
FT                   /id="PRO_0000394287"
FT   DOMAIN          209..409
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          471..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        489..503
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  59709 MW;  D6FEEB272BCD3F46 CRC64;
     MPPLLLLSAL IFLVNVLGGA PGHNPNRRAK MISIHSLSEL ERLKLQEAAY HELVARQFLS
     EFKPERALPT DRSNTFEKWF LILRGQERAV SLKTFGIRLE EVLVNELTRR KQVELRATMQ
     MQEAAGPATS GRRRGNAVQR MFGRIRRIFS GRRDEPFLPR EFTRRGRRGA VSADSLAELE
     GGALLLQTLQ LSRISFPIGQ RLLGSKRKMS LNPIAKQIPH VVEACCSFIE KHGLSTVGIF
     TLEYSEKRVR KLREEFDQGL DVVLDDSQNV HDVAALLKEF FRDMKDSLLP DDLYMSFLQT
     ATLKPQDQLS ALQLLVYLMP PCHSDTLERL LKVLHKVAEN CEDSIGIDGQ LVSGNRMTST
     NLALVFGSAL LKKGASAKRE SRKTRLGIDH YVASVSVVRA MIDNWDVLFQ VPPHIQKQVA
     KRVWKSSPEA LDFIRRRNLR KIQSERIKME EDALLSDPVE TSAEARAAIL GQSKPFDEGS
     SEEPAVPPGT ARSHDDEEGA GNPLILEQDR PLLRVPREKE AKTGIGYFFP