RHG36_HUMAN
ID RHG36_HUMAN Reviewed; 547 AA.
AC Q6ZRI8; B7Z234; B7Z439; Q5JRL9; Q5JRM0; Q5JRM1; Q96NU6;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Rho GTPase-activating protein 36;
DE Flags: Precursor;
GN Name=ARHGAP36;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5).
RC TISSUE=Adrenal gland, Amygdala, Testis, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC to an inactive GDP-bound state. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q6ZRI8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZRI8-2; Sequence=VSP_021358;
CC Name=3;
CC IsoId=Q6ZRI8-3; Sequence=VSP_021357;
CC Name=4;
CC IsoId=Q6ZRI8-4; Sequence=VSP_039236;
CC Name=5;
CC IsoId=Q6ZRI8-5; Sequence=VSP_039235;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH63790.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK054620; BAB70776.1; -; mRNA.
DR EMBL; AK128203; BAC87322.1; -; mRNA.
DR EMBL; AK294274; BAH11720.1; -; mRNA.
DR EMBL; AK296748; BAH12425.1; -; mRNA.
DR EMBL; AL590131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471107; EAX11793.1; -; Genomic_DNA.
DR EMBL; BC063790; AAH63790.1; ALT_INIT; mRNA.
DR CCDS; CCDS14628.1; -. [Q6ZRI8-1]
DR CCDS; CCDS65320.1; -. [Q6ZRI8-4]
DR CCDS; CCDS83489.1; -. [Q6ZRI8-3]
DR RefSeq; NP_001269536.1; NM_001282607.1. [Q6ZRI8-4]
DR RefSeq; NP_001317580.1; NM_001330651.1. [Q6ZRI8-3]
DR RefSeq; NP_659404.2; NM_144967.3. [Q6ZRI8-1]
DR RefSeq; XP_011529582.1; XM_011531280.1. [Q6ZRI8-3]
DR AlphaFoldDB; Q6ZRI8; -.
DR SMR; Q6ZRI8; -.
DR BioGRID; 127703; 119.
DR IntAct; Q6ZRI8; 72.
DR STRING; 9606.ENSP00000276211; -.
DR GlyGen; Q6ZRI8; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q6ZRI8; -.
DR PhosphoSitePlus; Q6ZRI8; -.
DR BioMuta; ARHGAP36; -.
DR DMDM; 74722974; -.
DR jPOST; Q6ZRI8; -.
DR MassIVE; Q6ZRI8; -.
DR PaxDb; Q6ZRI8; -.
DR PeptideAtlas; Q6ZRI8; -.
DR PRIDE; Q6ZRI8; -.
DR ProteomicsDB; 68137; -. [Q6ZRI8-1]
DR ProteomicsDB; 68138; -. [Q6ZRI8-2]
DR ProteomicsDB; 68139; -. [Q6ZRI8-3]
DR ProteomicsDB; 68140; -. [Q6ZRI8-4]
DR ProteomicsDB; 68141; -. [Q6ZRI8-5]
DR TopDownProteomics; Q6ZRI8-1; -. [Q6ZRI8-1]
DR Antibodypedia; 423; 116 antibodies from 22 providers.
DR DNASU; 158763; -.
DR Ensembl; ENST00000276211.10; ENSP00000276211.5; ENSG00000147256.12. [Q6ZRI8-1]
DR Ensembl; ENST00000370921.1; ENSP00000359959.1; ENSG00000147256.12. [Q6ZRI8-3]
DR Ensembl; ENST00000370922.5; ENSP00000359960.1; ENSG00000147256.12. [Q6ZRI8-4]
DR Ensembl; ENST00000412432.6; ENSP00000408515.2; ENSG00000147256.12. [Q6ZRI8-2]
DR Ensembl; ENST00000639280.1; ENSP00000492307.1; ENSG00000147256.12. [Q6ZRI8-3]
DR GeneID; 158763; -.
DR KEGG; hsa:158763; -.
DR MANE-Select; ENST00000276211.10; ENSP00000276211.5; NM_144967.4; NP_659404.2.
DR UCSC; uc004evz.5; human. [Q6ZRI8-1]
DR CTD; 158763; -.
DR DisGeNET; 158763; -.
DR GeneCards; ARHGAP36; -.
DR HGNC; HGNC:26388; ARHGAP36.
DR HPA; ENSG00000147256; Group enriched (adrenal gland, brain, pituitary gland).
DR MIM; 300937; gene.
DR neXtProt; NX_Q6ZRI8; -.
DR OpenTargets; ENSG00000147256; -.
DR PharmGKB; PA165756384; -.
DR VEuPathDB; HostDB:ENSG00000147256; -.
DR eggNOG; KOG2710; Eukaryota.
DR GeneTree; ENSGT00940000153904; -.
DR HOGENOM; CLU_012874_1_1_1; -.
DR InParanoid; Q6ZRI8; -.
DR OMA; NTFEKWF; -.
DR OrthoDB; 419555at2759; -.
DR PhylomeDB; Q6ZRI8; -.
DR TreeFam; TF316710; -.
DR PathwayCommons; Q6ZRI8; -.
DR SignaLink; Q6ZRI8; -.
DR BioGRID-ORCS; 158763; 12 hits in 690 CRISPR screens.
DR GenomeRNAi; 158763; -.
DR Pharos; Q6ZRI8; Tbio.
DR PRO; PR:Q6ZRI8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q6ZRI8; protein.
DR Bgee; ENSG00000147256; Expressed in adrenal tissue and 94 other tissues.
DR ExpressionAtlas; Q6ZRI8; baseline and differential.
DR Genevisible; Q6ZRI8; HS.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04376; RhoGAP_ARHGAP6; 1.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR041852; ARHGAP6_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037863; RHOGAP6/36.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12635; PTHR12635; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; GTPase activation; Reference proteome; Signal.
FT SIGNAL 1..40
FT /evidence="ECO:0000255"
FT CHAIN 41..547
FT /note="Rho GTPase-activating protein 36"
FT /id="PRO_0000256699"
FT DOMAIN 226..426
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 485..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..136
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021357"
FT VAR_SEQ 1..48
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039235"
FT VAR_SEQ 1..32
FT /note="MGGCIPFLKAARALCPRIMPPLLLLSAFIFLV -> M (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021358"
FT VAR_SEQ 1..31
FT /note="MGGCIPFLKAARALCPRIMPPLLLLSAFIFL -> MAWILDCLFASAFEPRP
FT RR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039236"
FT CONFLICT 340
FT /note="H -> R (in Ref. 1; BAH12425)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 547 AA; 61664 MW; 28EB8168F3928DF9 CRC64;
MGGCIPFLKA ARALCPRIMP PLLLLSAFIF LVSVLGGAPG HNPDRRTKMV SIHSLSELER
LKLQETAYHE LVARHFLSEF KPDRALPIDR PNTLDKWFLI LRGQQRAVSH KTFGISLEEV
LVNEFTRRKH LELTATMQVE EATGQAAGRR RGNVVRRVFG RIRRFFSRRR NEPTLPREFT
RRGRRGAVSV DSLAELEDGA LLLQTLQLSK ISFPIGQRLL GSKRKMSLNP IAKQIPQVVE
ACCQFIEKHG LSAVGIFTLE YSVQRVRQLR EEFDQGLDVV LDDNQNVHDV AALLKEFFRD
MKDSLLPDDL YMSFLLTATL KPQDQLSALQ LLVYLMPPCH SDTLERLLKA LHKITENCED
SIGIDGQLVP GNRMTSTNLA LVFGSALLKK GKFGKRESRK TKLGIDHYVA SVNVVRAMID
NWDVLFQVPP HIQRQVAKRV WKSSPEALDF IRRRNLRKIQ SARIKMEEDA LLSDPVETSA
EARAAVLAQS KPSDEGSSEE PAVPSGTARS HDDEEGAGNP PIPEQDRPLL RVPREKEAKT
GVSYFFP
