RHG36_MOUSE
ID RHG36_MOUSE Reviewed; 590 AA.
AC B1AUC7; A5D6Q0; A6H5U8; A8IP50; B1AUC6; B1AUC8;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Rho GTPase-activating protein 36;
GN Name=Arhgap36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RC STRAIN=ddY; TISSUE=Spinal cord;
RA Nishizawa M., Minami T., Ito S.;
RT "Mouse mRNAs expressed in the spinal cord.";
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC to an inactive GDP-bound state. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=B1AUC7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B1AUC7-2; Sequence=VSP_039238;
CC Name=3;
CC IsoId=B1AUC7-3; Sequence=VSP_039237;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM17960.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM17961.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB073967; BAF81999.1; -; mRNA.
DR EMBL; AL670305; CAM17960.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL670305; CAM17961.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL670305; CAM17962.1; -; Genomic_DNA.
DR EMBL; BC090672; AAH90672.1; -; mRNA.
DR EMBL; BC145645; AAI45646.1; -; mRNA.
DR CCDS; CCDS40963.1; -. [B1AUC7-1]
DR RefSeq; NP_001074592.1; NM_001081123.1. [B1AUC7-1]
DR RefSeq; XP_006541617.1; XM_006541554.3. [B1AUC7-3]
DR RefSeq; XP_006541618.1; XM_006541555.2. [B1AUC7-3]
DR RefSeq; XP_011249322.1; XM_011251020.1.
DR RefSeq; XP_017174122.1; XM_017318633.1. [B1AUC7-3]
DR AlphaFoldDB; B1AUC7; -.
DR SMR; B1AUC7; -.
DR STRING; 10090.ENSMUSP00000110554; -.
DR iPTMnet; B1AUC7; -.
DR PhosphoSitePlus; B1AUC7; -.
DR PaxDb; B1AUC7; -.
DR PRIDE; B1AUC7; -.
DR Antibodypedia; 423; 116 antibodies from 22 providers.
DR Ensembl; ENSMUST00000114904; ENSMUSP00000110554; ENSMUSG00000036198. [B1AUC7-1]
DR GeneID; 75404; -.
DR KEGG; mmu:75404; -.
DR UCSC; uc009tdc.2; mouse. [B1AUC7-1]
DR CTD; 158763; -.
DR MGI; MGI:1922654; Arhgap36.
DR VEuPathDB; HostDB:ENSMUSG00000036198; -.
DR eggNOG; KOG2710; Eukaryota.
DR GeneTree; ENSGT00940000153904; -.
DR InParanoid; B1AUC7; -.
DR OMA; NTFEKWF; -.
DR OrthoDB; 419555at2759; -.
DR PhylomeDB; B1AUC7; -.
DR TreeFam; TF316710; -.
DR BioGRID-ORCS; 75404; 1 hit in 75 CRISPR screens.
DR PRO; PR:B1AUC7; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; B1AUC7; protein.
DR Bgee; ENSMUSG00000036198; Expressed in chest muscle and 98 other tissues.
DR ExpressionAtlas; B1AUC7; baseline and differential.
DR Genevisible; B1AUC7; MM.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04376; RhoGAP_ARHGAP6; 1.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR041852; ARHGAP6_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037863; RHOGAP6/36.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12635; PTHR12635; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; GTPase activation; Reference proteome.
FT CHAIN 1..590
FT /note="Rho GTPase-activating protein 36"
FT /id="PRO_0000394288"
FT DOMAIN 214..414
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 526..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..34
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_039237"
FT VAR_SEQ 1..19
FT /note="MAWMLDCLFASAFEPRPRR -> MKL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039238"
FT CONFLICT 352
FT /note="V -> I (in Ref. 1; BAF81999 and 3; AAI45646)"
FT /evidence="ECO:0000305"
FT CONFLICT 538
FT /note="V -> E (in Ref. 1; BAF81999 and 3; AAI45646)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 590 AA; 66600 MW; 779F7137D07B6309 CRC64;
MAWMLDCLFA SAFEPRPRRV SVLGGAPGQN SDRSMDMVSI HSLSELERLK LQETAYHELV
ARHFLSEFKP DRALPTDRPN TLEKWFLMLR GQDRAASLKT FGIRLEEVLV NELTRRKQRE
LTPTMQVEDI NGSTGRRRRG NVVQRMLGRM RRFFSRRRNE PTLPREFTRR GRRGAVSADS
ADELENGALL LQILQLSQLS SPIGQRLLGS KRKMSLNPIA QQIPQIVETC CKFIEKHGLS
SVGIFTIEYS LRRVLELREL FDKGLDIVLD DSVNVHDVAE LLKEFFREMK DPLLPDDLYM
SFLLTATLKP KDQVSALQLL VYLMPPCHSD TLERLLKALH KITENCEDSI GVDGQLVPGN
RMTSTNLALV FGTALLKKGK LANKESRKTK LGIDHYVASV NVVRAMIDNW DILFQVPPHI
QKEVAKRVWK SSPEALDFIR RRNLRKIQSA RIKMEEDALL SDPVENSAEA QAAILAQSQP
FDEDPEGAPD VHEVLNDNLN YDFEDESDFE DQDHLDLAEV PYLDVIPNNE DTDSDADVIP
GPSEEPAVPA STAGSPDKEE GAAGNPPNAD RPLPRVPQGK KGKFATRFFP
