ID   RHG39_RAT               Reviewed;         101 AA.
AC   P18890;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   12-FEB-2003, sequence version 2.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Rho GTPase-activating protein 39;
DE   AltName: Full=Preoptic regulatory factor 2;
DE            Short=PORF-2;
DE   Flags: Fragment;
GN   Name=Arhgap39;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RX   PubMed=2293025; DOI=10.1210/mend-4-8-1205;
RA   Nowak F.V.;
RT   "Cloning of two hypothalamic cDNAs encoding tissue-specific transcripts in
RT   the preoptic area and testis.";
RL   Mol. Endocrinol. 4:1205-1210(1990).
CC   -!- TISSUE SPECIFICITY: Preoptic area and testis.
CC   -!- CAUTION: Was originally thought to be a precursor for a secreted GNRH-
CC       like peptide. {ECO:0000305|PubMed:2293025}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA37324.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X53232; CAA37324.1; ALT_FRAME; mRNA.
DR   AlphaFoldDB; P18890; -.
DR   SMR; P18890; -.
DR   STRING; 10116.ENSRNOP00000051450; -.
DR   PaxDb; P18890; -.
DR   UCSC; RGD:1593158; rat.
DR   RGD; 1593158; Arhgap39.
DR   eggNOG; ENOG502QR6X; Eukaryota.
DR   InParanoid; P18890; -.
DR   PhylomeDB; P18890; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR   GO; GO:0098794; C:postsynapse; IDA:SynGO.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0099173; P:postsynapse organization; ISO:RGD.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           <1..101
FT                   /note="Rho GTPase-activating protein 39"
FT                   /id="PRO_0000076094"
FT   DOMAIN          <1..96
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   NON_TER         1
SQ   SEQUENCE   101 AA;  11572 MW;  F216805966BE143E CRC64;
     YEQCIAHYES PEAAVAVVHA LPRINRMVLC YLIRFLQVFV QPANVAITKM DVSNLAMVMA
     PNCLRCQSDD PRVIFENTRK EMSFLRVLIQ HLDTSFMEGV L