RHG40_HUMAN
ID RHG40_HUMAN Reviewed; 622 AA.
AC Q5TG30;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Rho GTPase-activating protein 40;
DE AltName: Full=Rho-type GTPase-activating protein 40;
GN Name=ARHGAP40; Synonyms=C20orf95;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC to an inactive GDP-bound state. {ECO:0000250}.
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DR EMBL; AL035419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q5TG30; -.
DR SMR; Q5TG30; -.
DR IntAct; Q5TG30; 1.
DR STRING; 9606.ENSP00000362442; -.
DR iPTMnet; Q5TG30; -.
DR PhosphoSitePlus; Q5TG30; -.
DR BioMuta; ARHGAP40; -.
DR DMDM; 187611445; -.
DR MassIVE; Q5TG30; -.
DR PaxDb; Q5TG30; -.
DR PeptideAtlas; Q5TG30; -.
DR PRIDE; Q5TG30; -.
DR ProteomicsDB; 65092; -.
DR Antibodypedia; 51585; 55 antibodies from 9 providers.
DR Ensembl; ENST00000373345.9; ENSP00000362442.5; ENSG00000124143.11.
DR UCSC; uc061wyy.1; human.
DR GeneCards; ARHGAP40; -.
DR HGNC; HGNC:16226; ARHGAP40.
DR HPA; ENSG00000124143; Group enriched (breast, epididymis, esophagus, skin).
DR neXtProt; NX_Q5TG30; -.
DR VEuPathDB; HostDB:ENSG00000124143; -.
DR eggNOG; KOG2200; Eukaryota.
DR InParanoid; Q5TG30; -.
DR OMA; GDSGMKW; -.
DR PhylomeDB; Q5TG30; -.
DR TreeFam; TF314044; -.
DR PathwayCommons; Q5TG30; -.
DR Reactome; R-HSA-8980692; RHOA GTPase cycle.
DR Reactome; R-HSA-9013148; CDC42 GTPase cycle.
DR SignaLink; Q5TG30; -.
DR SIGNOR; Q5TG30; -.
DR ChiTaRS; ARHGAP40; human.
DR Pharos; Q5TG30; Tdark.
DR PRO; PR:Q5TG30; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q5TG30; protein.
DR Bgee; ENSG00000124143; Expressed in lower esophagus mucosa and 61 other tissues.
DR ExpressionAtlas; Q5TG30; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW GTPase activation; Reference proteome.
FT CHAIN 1..622
FT /note="Rho GTPase-activating protein 40"
FT /id="PRO_0000331532"
FT DOMAIN 270..469
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 42..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 133
FT /note="G -> R (in dbSNP:rs6100455)"
FT /id="VAR_042892"
FT VARIANT 413
FT /note="R -> L (in dbSNP:rs6070872)"
FT /id="VAR_042893"
FT VARIANT 463
FT /note="H -> N (in dbSNP:rs16987460)"
FT /id="VAR_042894"
SQ SEQUENCE 622 AA; 68908 MW; 4F2E42DDF1A64267 CRC64;
MDQLPQKNLL RLHPAGSAGC STGVESSSMD GFWMEVEQIQ QRDELREEDS GGNEGQLPEE
GEAESQWLQD TGLSGLLGGL GLDGDHQELL STLTQTQVAA VCRRLDIYAR SVRRQHKTPV
RDVRDVFGVF NSGKMSSENG DSGMKGAQLS SGASKFPPAA EPGGLQEQAG REEAFNMDSA
YSEQAAVLLQ RSRPSRGGTS AWGKCSLPKF TVPKGRLGVT RIGDLSLQDM RKVPSLALIE
LTALCDILGL DLKRSKAGKW KAAETRLFGV PLDSLLEADH KVLPSTQVPL VLQALLSCLE
KRGLDMEGIL RVPGSQARVK GLEQKLERDF YAGLFSWDEV HHNDASDLLK RFIRKLPTPL
LTAEYLPAFA VVPNIPNLKQ RLQVLHLLIL ILPEPNRNAL KALLEFLRKV VAREQHNKMT
LRNVSTVMAP NLFLHQGRPP KLPKGKEKQL AEGAAEVVQI MVHYQDLLWT VASFLVAQVR
KLNDSSSRRP QLCDAGLKTW LRRMHADRDK AGDGLEATPK VAKIQVVWPI KDPLKVPLTP
STKVAHVLRQ FTEHLSPGSK GQEDSEDMDS LLLHHRSMES ANILLYEVGG NINEHRLDPD
AYLLDLYRAN PHGEWVLKQN PT
