ID   RHG40_MOUSE             Reviewed;         672 AA.
AC   E9Q6X9; A2ACC5;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Rho GTPase-activating protein 40;
DE   AltName: Full=Rho-type GTPase-activating protein 40;
GN   Name=Arhgap40;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC       to an inactive GDP-bound state. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM23059.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL663091; CAM23059.1; ALT_INIT; Genomic_DNA.
DR   CCDS; CCDS50787.1; -.
DR   RefSeq; NP_001138487.1; NM_001145015.1.
DR   AlphaFoldDB; E9Q6X9; -.
DR   SMR; E9Q6X9; -.
DR   BioGRID; 244335; 19.
DR   STRING; 10090.ENSMUSP00000096736; -.
DR   PhosphoSitePlus; E9Q6X9; -.
DR   PaxDb; E9Q6X9; -.
DR   PRIDE; E9Q6X9; -.
DR   ProteomicsDB; 254969; -.
DR   Antibodypedia; 51585; 55 antibodies from 9 providers.
DR   Ensembl; ENSMUST00000099133; ENSMUSP00000096736; ENSMUSG00000074625.
DR   GeneID; 545481; -.
DR   KEGG; mmu:545481; -.
DR   UCSC; uc012cih.1; mouse.
DR   CTD; 343578; -.
DR   MGI; MGI:3649852; Arhgap40.
DR   VEuPathDB; HostDB:ENSMUSG00000074625; -.
DR   eggNOG; KOG2200; Eukaryota.
DR   GeneTree; ENSGT00940000162174; -.
DR   HOGENOM; CLU_023268_2_1_1; -.
DR   InParanoid; E9Q6X9; -.
DR   OMA; GDSGMKW; -.
DR   OrthoDB; 700544at2759; -.
DR   PhylomeDB; E9Q6X9; -.
DR   TreeFam; TF314044; -.
DR   Reactome; R-MMU-8980692; RHOA GTPase cycle.
DR   Reactome; R-MMU-9013148; CDC42 GTPase cycle.
DR   BioGRID-ORCS; 545481; 4 hits in 72 CRISPR screens.
DR   PRO; PR:E9Q6X9; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; E9Q6X9; protein.
DR   Bgee; ENSMUSG00000074625; Expressed in esophagus and 28 other tissues.
DR   ExpressionAtlas; E9Q6X9; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IBA:GO_Central.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   3: Inferred from homology;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..672
FT                   /note="Rho GTPase-activating protein 40"
FT                   /id="PRO_0000415822"
FT   DOMAIN          321..519
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT   REGION          43..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   672 AA;  74333 MW;  C5DAAB5E23BF5765 CRC64;
     MTEPSLLPAA KMEGLALLPL TSPCPRIPRA RISRQPGRWA HLGCSPGLST GPTNLQQHPQ
     KPRPADCSHS RLSWAESLSM DGFWMEVERI QQRAEVKKED CGEGRSQLLE GDTESQWLQD
     TGLSGLAGGL GLDGDHQGLL STLTQTQVAA VCRRLDIYAR SARRRQKAPV RDVRDIFGVF
     TSRELAPENG VSGMKWTKIN SEDSASPLRS AEPGGPQELA GMEEVFNMDS AYSEQAAVLL
     QRAWPSPGGT TAWGKGPLPR FRIPKGRLGV TRIGDLSSRD MKKIPPLALI ELTALYDILG
     LDLKRCKGGK WKGPDSGLFG VPLHSLLEAD HRVFPSTQVP LLLQALLSCL EKRGLDTEGI
     LRVPGSQARV KGLEQKLERD FYAGLVSWDK VHPNDASDLL KRFLRKLPVP LLTAEYLPAF
     ASVPDIPDLK QRLQALHLLV LLLPEPNRNT LKALLEFLRK VAAQEQHNKM TLWNVSTVMV
     PSLFLPRGRP PKLTKGGKQL AEGAAEVVCM MVQYQDLLWT VASFLVAQVR KLNDSNGRRS
     QLCDGGLKTW LWRTHVDRDK AGEGLEATPK VAKIQVQATW PSMDLLQVPL NPSTRVTHVL
     KLFTEHLNPG SQPEEGSENP NSLLSHNTKP VTFLVYEVGG NIGERRLDPD AYLLDLYRAN
     PHGEWVIRQS PT