RHGBA_MOUSE
ID RHGBA_MOUSE Reviewed; 987 AA.
AC Q80Y19; A2AL17; Q6ZQL1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Rho GTPase-activating protein 11A {ECO:0000305};
DE AltName: Full=Rho-type GTPase-activating protein 11A {ECO:0000305};
GN Name=Arhgap11a {ECO:0000312|MGI:MGI:2444300};
GN Synonyms=Kiaa0013 {ECO:0000303|PubMed:14621295};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284; SER-317 AND THR-322, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC to an inactive GDP-bound state. {ECO:0000250|UniProtKB:Q6P4F7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6P4F7}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC97844.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK129034; BAC97844.1; ALT_INIT; mRNA.
DR EMBL; AL772405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050875; AAH50875.1; -; mRNA.
DR CCDS; CCDS16562.1; -.
DR RefSeq; NP_852081.2; NM_181416.3.
DR AlphaFoldDB; Q80Y19; -.
DR SMR; Q80Y19; -.
DR BioGRID; 230736; 6.
DR STRING; 10090.ENSMUSP00000099604; -.
DR iPTMnet; Q80Y19; -.
DR PhosphoSitePlus; Q80Y19; -.
DR EPD; Q80Y19; -.
DR jPOST; Q80Y19; -.
DR MaxQB; Q80Y19; -.
DR PaxDb; Q80Y19; -.
DR PeptideAtlas; Q80Y19; -.
DR PRIDE; Q80Y19; -.
DR ProteomicsDB; 254974; -.
DR DNASU; 228482; -.
DR Ensembl; ENSMUST00000102545; ENSMUSP00000099604; ENSMUSG00000041219.
DR Ensembl; ENSMUST00000110949; ENSMUSP00000106574; ENSMUSG00000041219.
DR GeneID; 228482; -.
DR KEGG; mmu:228482; -.
DR UCSC; uc008lpr.2; mouse.
DR CTD; 9824; -.
DR MGI; MGI:2444300; Arhgap11a.
DR VEuPathDB; HostDB:ENSMUSG00000041219; -.
DR eggNOG; KOG2710; Eukaryota.
DR GeneTree; ENSGT00940000155312; -.
DR HOGENOM; CLU_010134_1_0_1; -.
DR InParanoid; Q80Y19; -.
DR OMA; RQPIRHK; -.
DR OrthoDB; 213929at2759; -.
DR PhylomeDB; Q80Y19; -.
DR TreeFam; TF332212; -.
DR Reactome; R-MMU-8980692; RHOA GTPase cycle.
DR BioGRID-ORCS; 228482; 6 hits in 73 CRISPR screens.
DR ChiTaRS; Arhgap11a; mouse.
DR PRO; PR:Q80Y19; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q80Y19; protein.
DR Bgee; ENSMUSG00000041219; Expressed in cleaving embryo and 221 other tissues.
DR ExpressionAtlas; Q80Y19; baseline and differential.
DR Genevisible; Q80Y19; MM.
DR GO; GO:0005759; C:mitochondrial matrix; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; -; 1.
DR InterPro; IPR042869; ARHGAP11A/B.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15670; PTHR15670; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW GTPase activation; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..987
FT /note="Rho GTPase-activating protein 11A"
FT /id="PRO_0000267214"
FT DOMAIN 52..239
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 297..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 284
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 305
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT MOD_RES 315
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT MOD_RES 317
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 322
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 338
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT MOD_RES 339
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT MOD_RES 481
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT MOD_RES 505
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT MOD_RES 581
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT MOD_RES 655
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT MOD_RES 819
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT MOD_RES 840
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4F7"
FT CONFLICT 723
FT /note="G -> V (in Ref. 1; BAC97844 and 3; AAH50875)"
FT /evidence="ECO:0000305"
FT CONFLICT 867
FT /note="L -> H (in Ref. 1; BAC97844 and 3; AAH50875)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 987 AA; 108436 MW; E7566F732548997D CRC64;
MWDQRLVRLA LLQQLRAVYG IKVKGGRGQC DRRRHETAAT EIKGKVFGVP FNSLPHSVVP
EFGHIPSFLV DACASLKEHI HTEGLFRKSG SVVRLKALKS KLDQGEACLS SALPCDVAGL
LKQFFRELPE PVLPADLHEA LFKAQQLGAE ERNKATLLLS CLMANPTVDI LRYFFNFLKS
VSLRASENKM DSSNLAVIFA PNLLQTSEGH EKMSANTEKK LRLQAAVVQT FIDCASDIGR
VPDFILEKIP AMLGIDGLCT TPSLEGFEGD FETPGECKRK RRQSVGDFVN GALNKLKSSR
TPSITPQQDR TAQASASPLI LTPSVKRKLP GESSHAFSSK KRKSIKHNLN FELLPSHFFS
SNSTPVSVHL DTSPDGSSQT SLSPIAMSGN HLVSTELRRS KRIASKKVYR VESGKAGCFS
PKVSRKEKTR RSLRLKFSLG KNRDSDGCSV INRYENVGRR LANQQNLKSR IDSVKTGLLF
SPDIDERLLK KGSEKISKSE EHLLTPDQLD GTGYRMSWTE PSNSSFQDMS ANGTSPIMQN
LEVKSFSLEP DITVEKSPVV SCELRPSTFH SQPDSSVLSL SGDEGNLASE TLQKIQKAFS
ESGSDLHMVI NHEQSSVTNT GEEVEFRDVT VTESKGHDGS CAGEEENCPS ERNFSPDQSP
EFAREADEEC YSTQMKVECE GLHSETPKAD PLILQAFPGE EPAEEPQSPR NQLSTPSRGN
ENGGESAGAS GAPGEDESTC SVAVLSKPRP QRLSRQQSLV EKCDSVAPGA LQVTEHGKVS
DHIQWFNKLS LNEPNRGKVK SPLKFQRTPV RQSVRRINSL LEYGRQPVRQ KLAIFGDAAS
PLVKSVSCDS ALPSCVQNTS KGPTAPLITS GLEAQKSTSC NKSSVELTSK SFTKMKRHPD
PLSASLGTPR LCKQENKSNG HIKFPLDDLT NHERLKFVVN NNVAFSPGMK NRVVRKPSEK
ERVWYKGSPK NPIGKTQLLP TSKPVDL
