RHGB_DICDI
ID RHGB_DICDI Reviewed; 600 AA.
AC Q8I0L6; Q54VL4;
DT 15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Rhesus-like glycoprotein B;
DE AltName: Full=Rh50-like protein rhgB;
GN Name=rhgB; ORFNames=DDB_G0280059;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX2;
RX PubMed=16227429; DOI=10.1073/pnas.0507886102;
RA Huang C.-H., Peng J.;
RT "Evolutionary conservation and diversification of Rh family genes and
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May be a carbon dioxide/bicarbonate transporter.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000305}.
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DR EMBL; AF447924; AAN76727.1; -; mRNA.
DR EMBL; AF447925; AAN76728.1; -; mRNA.
DR EMBL; AAFI02000035; EAL67256.1; -; Genomic_DNA.
DR RefSeq; XP_641341.1; XM_636249.1.
DR AlphaFoldDB; Q8I0L6; -.
DR SMR; Q8I0L6; -.
DR STRING; 44689.DDB0214831; -.
DR PaxDb; Q8I0L6; -.
DR EnsemblProtists; EAL67256; EAL67256; DDB_G0280059.
DR GeneID; 8622475; -.
DR KEGG; ddi:DDB_G0280059; -.
DR dictyBase; DDB_G0280059; rhgB.
DR eggNOG; KOG3796; Eukaryota.
DR HOGENOM; CLU_021386_1_0_1; -.
DR InParanoid; Q8I0L6; -.
DR OMA; ENCFEDE; -.
DR PhylomeDB; Q8I0L6; -.
DR Reactome; R-DDI-1237044; Erythrocytes take up carbon dioxide and release oxygen.
DR Reactome; R-DDI-1247673; Erythrocytes take up oxygen and release carbon dioxide.
DR Reactome; R-DDI-444411; Rhesus glycoproteins mediate ammonium transport.
DR PRO; PR:Q8I0L6; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; ISS:dictyBase.
DR GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR GO; GO:0072488; P:ammonium transmembrane transport; ISS:dictyBase.
DR Gene3D; 1.10.3430.10; -; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..600
FT /note="Rhesus-like glycoprotein B"
FT /id="PRO_0000390405"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..73
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..145
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..325
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..361
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 383..411
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..600
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 471..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..557
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 600 AA; 66958 MW; 4921944FE3F4F4D4 CRC64;
MSKDEHKLPL SKRKESIIFM MILFAFQVFM VVLFSVWVRY SKNEVNYSTL TPEQLQELEA
TGGVVQEEVT NIYGYFRDIN IMIFFGFGFL MTFLRRYGYS ALGYTFIISA LVAQWSVLIY
GFFETVDHKN DHGGDYASTF EMSQTVLLQG LFCAGAVMIS YGAVLGRVTP LQMLVVGIFE
PIFYFLNMFI GEMNLEAIDV GGGMYIHLFG SVFGLTIAWF LTDKKSKDCE DNSPSYTGDY
FAMAGTLFLW MMWPSFNAAI APLGEPQFRA IANTFLSLTA STIATFIVTR LFGHLGHKID
MVHVQNSSLA GGVVQGCLAH MNINPGGAIG MGFLAGVISV IGYLFISPFL QRRFNIQDTC
GIHNLHFMPG FIGSIAACIA AWKGLNDRSL YNPIEFNQIF RAGEDQARNN AAATFISIGI
AIAGGLFVGM ILKALKKVGG LKAKQYYQDS AFWHVPIDYP KDVEYVVEQN NLPMPTTDNG
DNVVGGGVEM KKHNNNNNKK ENGYRRDLIR LLETLVRNEQ STDSSYSDSD SSDEEEKERR
IRKLAKKSYR RSKKSHSEHQ PQHQPEESTF NNNNNNNNNN ATAETTDNGG SSTNSPTSKV
