ID   RHIC_ORYRH              Reviewed;         142 AA.
AC   O76145;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Rhinocerosin;
DE   Flags: Precursor;
OS   Oryctes rhinoceros (Coconut rhinoceros beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Scarabaeiformia;
OC   Scarabaeidae; Dynastinae; Oryctes.
OX   NCBI_TaxID=72550;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=9738915; DOI=10.1046/j.1432-1327.1998.2550734.x;
RA   Yang J., Yamamoto M., Ishibashi J., Taniai K., Yamakawa M.;
RT   "Isolation, cDNA cloning and gene expression of an antibacterial protein
RT   from larvae of the coconut rhinoceros beetle, Oryctes rhinoceros.";
RL   Eur. J. Biochem. 255:734-738(1998).
CC   -!- FUNCTION: Has strong antibacterial activity against E.coli,
CC       Streptococcus pyogenes, Staphylococcus aureus but not against
CC       Pseudomonas aeruginosa.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in the fat body and the
CC       Malpighian tubules, and weakly expressed in hemocytes and midgut.
CC   -!- SIMILARITY: Belongs to the coleoptericin family. {ECO:0000305}.
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DR   EMBL; AB010824; BAA31506.1; -; mRNA.
DR   AlphaFoldDB; O76145; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR009382; Coleoptericin.
DR   Pfam; PF06286; Coleoptericin; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..70
FT                   /id="PRO_0000004988"
FT   CHAIN           71..142
FT                   /note="Rhinocerosin"
FT                   /id="PRO_0000004989"
FT   REGION          72..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   142 AA;  16005 MW;  85F44CAD26163B64 CRC64;
     MMKLYIVFGF IAFSAAYVVP EGYYEPEYYP ADGYESERVA RASPAELIFD EDLADEPEVE
     EPQYYIRTRR SLQPGAPNFP MPGSQLPTSI TSNIEKQGPN TAATINAQHK TDRYDVGATW
     SKVIRGPGRS KPNWSIGGTY RW