ID   RHLF_PANTR              Reviewed;         417 AA.
AC   Q28812;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=RH-like protein IIF;
DE   AltName: Full=Rhesus-like protein IIF;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7993375; DOI=10.1007/bf00554623;
RA   Salvignol I., Blancher A., Calvas P., Clayton J., Socha W.W., Colin Y.,
RA   Ruffie J.;
RT   "Molecular genetics of chimpanzee Rh-related genes: their relationship with
RT   the R-C-E-F blood group system, the chimpanzee counterpart of the human
RT   rhesus system.";
RL   Biochem. Genet. 32:201-221(1994).
CC   -!- FUNCTION: May be part of an oligomeric complex which is likely to have
CC       a transport or channel function in the erythrocyte membrane.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC       subfamily. {ECO:0000305}.
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DR   EMBL; L37048; AAA65622.1; -; mRNA.
DR   PIR; I37003; I37003.
DR   RefSeq; NP_001123215.1; NM_001129743.1.
DR   AlphaFoldDB; Q28812; -.
DR   SMR; Q28812; -.
DR   GeneID; 456645; -.
DR   KEGG; ptr:456645; -.
DR   OrthoDB; 910733at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR   GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   InterPro; IPR002229; RhesusRHD.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   PRINTS; PR00342; RHESUSRHD.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..417
FT                   /note="RH-like protein IIF"
FT                   /id="PRO_0000168197"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   417 AA;  45268 MW;  C7F71DF67716D3EF CRC64;
     MSSKYPRSVR CCLPLCALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI
     GFGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPPGKVVITL FSIRLATTSA
     LSVLISAGAV LGYVNLVQLV VMVLVEVTAL GTMRMVISNI FNTDYHMNMM HFYLFTAYFG
     VTVAWCLPKP LPDVKEDKDQ IATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN
     TYYALAVSVV TAISGSSLAH PQGKISMTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV
     AGLISIGGAK CGPGCCNRVL GIPDSSVMHY NFSLLGLLGE IIYIVLVVRH TVWNGNGMIG
     FQVLLSMGEL SLAIAIALTS GLLTGLLLNL KIWKAPHVAK YSDDQVFWKF PHLAVGF