ID   RHLR_PANTR              Reviewed;         417 AA.
AC   Q28814;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=RH-like protein IIR;
DE   AltName: Full=Rhesus-like protein IIR;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7993375; DOI=10.1007/bf00554623;
RA   Salvignol I., Blancher A., Calvas P., Clayton J., Socha W.W., Colin Y.,
RA   Ruffie J.;
RT   "Molecular genetics of chimpanzee Rh-related genes: their relationship with
RT   the R-C-E-F blood group system, the chimpanzee counterpart of the human
RT   rhesus system.";
RL   Biochem. Genet. 32:201-221(1994).
CC   -!- FUNCTION: May be part of an oligomeric complex which is likely to have
CC       a transport or channel function in the erythrocyte membrane.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC       subfamily. {ECO:0000305}.
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DR   EMBL; L37050; AAA65624.1; -; mRNA.
DR   PIR; I37005; I37005.
DR   AlphaFoldDB; Q28814; -.
DR   SMR; Q28814; -.
DR   STRING; 9598.ENSPTRP00000055141; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR   GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   InterPro; IPR002229; RhesusRHD.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   PRINTS; PR00342; RHESUSRHD.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..417
FT                   /note="RH-like protein IIR"
FT                   /id="PRO_0000168198"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   417 AA;  45431 MW;  35FC132CDAD798E0 CRC64;
     MSSKYPRSVR RCLPLCALTL EAALILLFYF FTQYDASLED QKGLVASYQV GQDLTVMAAI
     GFGFLTSSFR RHSWSSVAFS LFMLALGVQW AILLDGFLSQ FPPGKVVITL FSIRLATTSA
     LSVLISVDAV LGKVNLVQLV VMVLVEVTAL GTVRMVISNI FNTDYHMNLM HIYVFAAYFG
     LSVAWCLPKP LPKGTEDKDQ IATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN
     TYYAVAVSVV TAISGSSLAH PQGKISMSYM HNAVLAGGVA VGTSCHLIPS PWLAMVLGLV
     AGLISVGGAK YLPGCCNRVL GIPHSSVMGS NFSWLGLLGE IIYIVLVVRH TIWNGNGMIG
     FQVLLRIGEF SLATTIALTS GLLTGLLLNL KIWKAPHEAK YFDDQVFWKF PHLAVGF