ID   RHL_HYLPI               Reviewed;         354 AA.
AC   Q28446;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=RH-like protein;
DE   AltName: Full=Rhesus-like protein;
OS   Hylobates pileatus (Pileated gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Hylobates.
OX   NCBI_TaxID=9589;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7993375; DOI=10.1007/bf00554623;
RA   Salvignol I., Blancher A., Calvas P., Clayton J., Socha W.W., Colin Y.,
RA   Ruffie J.;
RT   "Molecular genetics of chimpanzee Rh-related genes: their relationship with
RT   the R-C-E-F blood group system, the chimpanzee counterpart of the human
RT   rhesus system.";
RL   Biochem. Genet. 32:201-221(1994).
CC   -!- FUNCTION: May be part of an oligomeric complex which is likely to have
CC       a transport or channel function in the erythrocyte membrane.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC       subfamily. {ECO:0000305}.
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DR   EMBL; L37051; AAA65625.1; -; mRNA.
DR   PIR; I37053; I37053.
DR   AlphaFoldDB; Q28446; -.
DR   SMR; Q28446; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   InterPro; IPR002229; RhesusRHD.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   PRINTS; PR00342; RHESUSRHD.
PE   2: Evidence at transcript level;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..354
FT                   /note="RH-like protein"
FT                   /id="PRO_0000168193"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   354 AA;  38548 MW;  1723D0494F868CE4 CRC64;
     MSSKYPRSVR GCLPLWALTL EAALILLFFF FTHYDASLED QKGLVATYQV GQDLTVMAAL
     GLGFLTSNLR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPPGKVVIKL LSIRLATMSA
     MSSLISVGAV LGKVNLVQLV VMVLVELTAF GTMRMVINNI FKTDYHVNIM HIHVFAAYFG
     LTVAWCLPKP PPEGTEDKEQ IANSPSLSAM LGALFLWIFW PSFNSALLTN PIERKNAVFN
     TYYALAVSTV TAISVSSLAH PQGKINMTYM HNAVLAGGVA VGTSCHLISS PWLAMVLGLV
     AGLISIGGAK CLPDWLPDPL QHWGTQLGHG DSSHVWFPDR FAPKSQNMES TSCG