ID   RHL_MACFA               Reviewed;         417 AA.
AC   Q28481;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=RH-like protein;
DE   AltName: Full=Rhesus-like protein;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7993375; DOI=10.1007/bf00554623;
RA   Salvignol I., Blancher A., Calvas P., Clayton J., Socha W.W., Colin Y.,
RA   Ruffie J.;
RT   "Molecular genetics of chimpanzee Rh-related genes: their relationship with
RT   the R-C-E-F blood group system, the chimpanzee counterpart of the human
RT   rhesus system.";
RL   Biochem. Genet. 32:201-221(1994).
CC   -!- FUNCTION: May be part of an oligomeric complex which is likely to have
CC       a transport or channel function in the erythrocyte membrane.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L37054; AAA65628.1; -; mRNA.
DR   PIR; I84434; I84434.
DR   AlphaFoldDB; Q28481; -.
DR   SMR; Q28481; -.
DR   STRING; 9541.XP_005544454.1; -.
DR   eggNOG; KOG3796; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   InterPro; IPR002229; RhesusRHD.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   PRINTS; PR00342; RHESUSRHD.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..417
FT                   /note="RH-like protein"
FT                   /id="PRO_0000168194"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   417 AA;  46009 MW;  E22BEEB5DCBF0569 CRC64;
     MSSKYPRSVR CCLPLWALTL EAALILLFFF FTYYDASLED QKGLVASYQV CQDLTVMAVL
     GLGFFTSNLR RNSWSSVAFN LFLLALGVQW AILLDGFLSQ FSPGKVVIKL FSIRLATRST
     TSMLISMNAV LGKVNLAQLV VMELVELTVF GTMRIVIYNI FKIDYGMNMM HIHVFAAYFG
     LTVAWCLPKP LPKGTEDKYQ TTTSPSLFAM LGTLFLWMFW PTFNSALLLN PIERKNAVFS
     TYYALAVSAV TAISVSSLAH PQRKINMTYM PNAGLAGGVA VGASCHVIHS PWIAMVLGLV
     AGLISFGGAK CLPVCFNRVL GIHESHSMHY TFGLPALLGE ITYIVLMALR VFWASSNMIG
     FQVLLSTGTL SLAMAMSITS GLLTGLLLNL KIWKGPHVAK YFDDQAFWEF PHLAVGF