ID   RHL_MACMU               Reviewed;         417 AA.
AC   Q28849;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=RH-like protein;
DE   AltName: Full=Rhesus-like protein;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7909570; DOI=10.1007/bf00166163;
RA   Mouro I., le van Kim C., Cherif-Zahar B., Salvignol I., Blancher A.,
RA   Cartron J.-P., Colin Y.;
RT   "Molecular characterization of the Rh-like locus and gene transcripts from
RT   the rhesus monkey (Macaca mulatta).";
RL   J. Mol. Evol. 38:169-176(1994).
CC   -!- FUNCTION: May be part of an oligomeric complex which is likely to have
CC       a transport or channel function in the erythrocyte membrane.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC       subfamily. {ECO:0000305}.
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DR   EMBL; S70343; AAB30637.1; -; mRNA.
DR   RefSeq; NP_001028136.3; NM_001032964.3.
DR   AlphaFoldDB; Q28849; -.
DR   SMR; Q28849; -.
DR   STRING; 9544.ENSMMUP00000014604; -.
DR   GeneID; 613023; -.
DR   KEGG; mcc:613023; -.
DR   CTD; 6006; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0008519; F:ammonium transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR   GO; GO:0072488; P:ammonium transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3430.10; -; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   InterPro; IPR002229; RhesusRHD.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   PRINTS; PR00342; RHESUSRHD.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..417
FT                   /note="RH-like protein"
FT                   /id="PRO_0000168195"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         2..56
FT                   /note="Missing (in Mac-B)"
FT   VARIANT         71
FT                   /note="R -> K (in Mac-B)"
FT   VARIANT         107
FT                   /note="A -> V (in Mac-B)"
FT   VARIANT         192
FT                   /note="P -> L (in Mac-B)"
FT   VARIANT         262
FT                   /note="G -> R (in Mac-B)"
FT   VARIANT         343
FT                   /note="Y -> C (in Mac-B)"
SQ   SEQUENCE   417 AA;  45803 MW;  CE54577BBBE433AF CRC64;
     MSSKYPRSVR CCLPLWALTL EAALILLFFF FTYYDASLED QKGLVASYQV CQDLTVMAVL
     GLGFFTSNLR RNSWSSVAFN LFLLALGVQW AILLDGFLSQ FSPGKVAIKL FSIRLATRST
     MSMLISMNAV LGKVNLVQLV VMELVELTVF GTMRIVINNI FKIDYGMNMM HIHVFAAYFG
     LTVAWCLPKP LPKGTEDKYQ TTTSPSLFAM LGTLFLWMFW PTFNSALLLN PIERKNAVFS
     TYYALAVSAV TAISVSSLAH PGGKINMTYM HNAALAGGVA LSASCHVIHS PWIAMVLGLV
     AGLISIGGAK CLPVCFNRVL GIHESHSVHY TFGLPALLGE ITYIVLMALR VVWASSNMIG
     FQVLLSTGTL SLAMAMSITS GLLTGLLLNL KIWKGPHVAK YFDDQAFWEF PHLAVGF