RHMT_ECOLI
ID RHMT_ECOLI Reviewed; 429 AA.
AC P76470; P76930;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Inner membrane transport protein RhmT;
GN Name=rhmT; Synonyms=yfaV; OrderedLocusNames=b2246, JW2240;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Part of the rhmRDTA operon involved in L-rhamnonate
CC utilization.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Phthalate
CC permease family. {ECO:0000305}.
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DR EMBL; U00096; AAC75306.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA16070.1; -; Genomic_DNA.
DR PIR; D64995; D64995.
DR RefSeq; NP_416749.4; NC_000913.3.
DR RefSeq; WP_000100890.1; NZ_LN832404.1.
DR AlphaFoldDB; P76470; -.
DR SMR; P76470; -.
DR BioGRID; 4260489; 115.
DR STRING; 511145.b2246; -.
DR TCDB; 2.A.1.14.35; the major facilitator superfamily (mfs).
DR PaxDb; P76470; -.
DR PRIDE; P76470; -.
DR EnsemblBacteria; AAC75306; AAC75306; b2246.
DR EnsemblBacteria; BAA16070; BAA16070; BAA16070.
DR GeneID; 945796; -.
DR KEGG; ecj:JW2240; -.
DR KEGG; eco:b2246; -.
DR PATRIC; fig|511145.12.peg.2337; -.
DR EchoBASE; EB3837; -.
DR eggNOG; COG2271; Bacteria.
DR HOGENOM; CLU_001265_0_0_6; -.
DR InParanoid; P76470; -.
DR OMA; KGQSICA; -.
DR PhylomeDB; P76470; -.
DR BioCyc; EcoCyc:B2246-MON; -.
DR PRO; PR:P76470; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031224; C:intrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..429
FT /note="Inner membrane transport protein RhmT"
FT /id="PRO_0000121390"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..54
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..143
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..174
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..242
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..324
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..361
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 383..394
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 416..429
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 429 AA; 46294 MW; 6C22A0A083BA99BC CRC64;
MSTALLDAVV KKNRVRLIPF MLALYVLAFL DRSNIGFAKQ TYQIDTGLSN EAYALGAGIF
FVVYAFLGVP ANLLMRKLGA RTWIGTTTLL WGFLSAAMAW ADTEAKFLIV RTLLRAAEAG
FFPGMIYLTS QWFPQRNRAS IMGLFYMGAP LALTLGSPLS GALLEMHGFM GHPGWFWMFV
IEGLLAVGAG VFTFFWLDDT PEQARFLSKQ EKTLLINQLA SEEQQKVTSR LSDALRNGRV
WQLAIIYLTI QVAVYGLIFF LPTQVAALLG TKVGFTASVV TAIPWVAALF GTWLIPRYSD
KTGERRNVAA LTLLAAGIGI GLSGLLSPVM AIVALCVAAI GFIAVQPVFW TMPTQLLSGT
ALAAGIGFVN LFGAVGGFIA PILRVKAETL FASDAAGLLT LAAVAVIGSL IIFTLRVNRT
VAQTDVAHH
