ID   RHN2A_XENLA             Reviewed;         683 AA.
AC   Q6DJJ6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Rhophilin-2-A;
DE   AltName: Full=GTP-Rho-binding protein 2-A;
GN   Name=rhpn2-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds specifically to GTP-Rho. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RhoA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RHPN family. {ECO:0000305}.
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DR   EMBL; BC075182; AAH75182.1; -; mRNA.
DR   RefSeq; NP_001086373.1; NM_001092904.1.
DR   AlphaFoldDB; Q6DJJ6; -.
DR   SMR; Q6DJJ6; -.
DR   DNASU; 444802; -.
DR   GeneID; 444802; -.
DR   KEGG; xla:444802; -.
DR   CTD; 444802; -.
DR   Xenbase; XB-GENE-17330332; rhpn2.S.
DR   OrthoDB; 641122at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 444802; Expressed in stomach and 15 other tissues.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.40.280; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR011072; HR1_rho-bd.
DR   InterPro; IPR036274; HR1_rpt_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   Pfam; PF03097; BRO1; 1.
DR   Pfam; PF02185; HR1; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   SMART; SM01041; BRO1; 1.
DR   SMART; SM00742; Hr1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF46585; SSF46585; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS51180; BRO1; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS51860; REM_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..683
FT                   /note="Rhophilin-2-A"
FT                   /id="PRO_0000340663"
FT   DOMAIN          25..99
FT                   /note="REM-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01207"
FT   DOMAIN          110..501
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   DOMAIN          515..592
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
SQ   SEQUENCE   683 AA;  77134 MW;  977A7DC6EF53FD2F CRC64;
     MTDALLPGSL NGKRLSEQNY FRKGKSIAQT GRSKLQNQRA SLNQQILKAM RMRVGAENLL
     RATSNNKIRE QVLLELSFVN SNLQRLKEEL ERLNISVEVY QHTEQDSNIP LIPLGLKETK
     DVDFTTAFKD FISEHYSEDA SEYENELADL MDLRQACRTP SRDEAGVELL VSYFQQLGYL
     ENRFFPPSRN LGILFTWYDS FTGVPVSQPN ISLEKASILF NIAALYTQIG TRCNRQTKIG
     LEEAVTAFQK ATGVLNYLKE TFTHTPSYDM SPAMLGVLIK MLLAEAHECY FEKMILSGIQ
     NEFCTLLKAA QEAAKVGEVH MQVYTLMNQA PIKENVPYSW SVMVQVKAEH YKALANYFVA
     IILIDYQLSL SDDEDKQEKA ISQLYDSMPE GLTAQTILKD QQQRTLLGKA HLSKAIRSHE
     EAIRFSTLCS TLRQIDVLQK ILSAFHQRSQ LKFSQHQKPD DFLDLLSAPD IVSKTEYQAK
     TISPQLSKDK VTDIFQRLGP LSVFSVKQRW SAPRKICITK EDGDFGFVLR GDCPVQVISL
     DPLCPAATEG LKEGDYIVSV AGKDCKWCST SQVMDMLQAT GKQSIEIQVI SIQDQTYSMP
     TKSATYYAGM QKTYSLVCLT MDNVKHTKTQ KATKKLSFLS WGFRNRQKAA STLCLPSEVK
     GKPKTDNLFS FPDNSLCSES VLY