ID   RHN2B_XENLA             Reviewed;         683 AA.
AC   Q63ZR5;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Rhophilin-2-B;
DE   AltName: Full=GTP-Rho-binding protein 2-B;
GN   Name=rhpn2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds specifically to GTP-Rho. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RhoA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RHPN family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC082845; AAH82845.1; -; mRNA.
DR   RefSeq; NP_001088054.1; NM_001094585.1.
DR   AlphaFoldDB; Q63ZR5; -.
DR   SMR; Q63ZR5; -.
DR   DNASU; 494748; -.
DR   GeneID; 494748; -.
DR   KEGG; xla:494748; -.
DR   CTD; 494748; -.
DR   Xenbase; XB-GENE-966653; rhpn2.L.
DR   OrthoDB; 641122at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 494748; Expressed in lung and 18 other tissues.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.40.280; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR011072; HR1_rho-bd.
DR   InterPro; IPR036274; HR1_rpt_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   Pfam; PF03097; BRO1; 1.
DR   Pfam; PF02185; HR1; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   SMART; SM01041; BRO1; 1.
DR   SMART; SM00742; Hr1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF46585; SSF46585; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS51180; BRO1; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS51860; REM_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..683
FT                   /note="Rhophilin-2-B"
FT                   /id="PRO_0000340664"
FT   DOMAIN          25..99
FT                   /note="REM-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01207"
FT   DOMAIN          110..501
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   DOMAIN          515..592
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
SQ   SEQUENCE   683 AA;  77044 MW;  C598F85B3352611B CRC64;
     MTDALLPANL NAKRLSEQNY FRKGKSIAQT GRSKLQNQRA ILNQQILKAM RMRAGAENLL
     RATANNKIRE QVLLELSFVN SNLQRLKEEL ERLNISVEVY QHTEQASNIP LIPLGLKETK
     DVDFTTAFKD FILEHYSEDA SEYENELADL MDLRQACRTP SRDEAGVELL VSYFQQLGYL
     ENRFFPPSRN IGILFTWYDS FTGVPVSQPN ISLEKASILF NIAALYSQIG TRCNRQTKIG
     LEEAVTTFQK AAGVLNYLKE TFTHTPSYDM SPAMLGALIK MLLAEAHECY FEKMILSGIQ
     NEFCTLLKAA QEAAKVSEVH MQVYTLMNQA PIKENVPYSW SVMVQVKAEH YKALANYFVA
     ITLIDYQLNL SDDEDKQEKA ISQLYDSMPE GLTAQTILKD QQQRTLLGKA HLSKAIRSHE
     EAIRFSTLCS TLRQIDVLQL ILSAFHQRSL LKFSQHQKPD DFLDLLSAPD IVSKTEYQAE
     TIPPQLSKDK VTDIFQRLGP LSIFSVKQRW SAPRKMCITK EDGDFGFVLK GDCPVQVISL
     DPLCPAATEG LKEGDYIVSV AGKDCKWCST SQVMDMLQET GQDSIEIQVI SIQDQTNSLA
     NKSATYYAGM QKTYSLVCLT MDNDKNTKTQ KATKKLSFLS WGFKNRQKAA STICLPSEVK
     GKPKTDMVFS FPDNSLSTES ALY