ID   RHNO1_BOVIN             Reviewed;         241 AA.
AC   Q1LZE2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=RAD9, HUS1, RAD1-interacting nuclear orphan protein 1;
GN   Name=RHNO1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in DNA damage response (DDR) signaling upon
CC       genotoxic stresses such as ionizing radiation (IR) during the S phase.
CC       Recruited to sites of DNA damage through interaction with the 9-1-1
CC       cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent
CC       manner. Required for the progression of the G1 to S phase transition.
CC       Plays a role in the stimulation of CHEK1 phosphorylation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RAD9A, RAD18, TOPBP1 and UBE2N. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC       Note=Localizes to sites of DNA damage in a H2AX-independent manner.
CC       {ECO:0000250}.
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DR   EMBL; BC116052; AAI16053.1; -; mRNA.
DR   RefSeq; NP_001069099.1; NM_001075631.1.
DR   RefSeq; XP_005207299.1; XM_005207242.2.
DR   AlphaFoldDB; Q1LZE2; -.
DR   STRING; 9913.ENSBTAP00000021104; -.
DR   PaxDb; Q1LZE2; -.
DR   PRIDE; Q1LZE2; -.
DR   Ensembl; ENSBTAT00000021104; ENSBTAP00000021104; ENSBTAG00000015878.
DR   Ensembl; ENSBTAT00000068838; ENSBTAP00000059471; ENSBTAG00000015878.
DR   GeneID; 513642; -.
DR   KEGG; bta:513642; -.
DR   CTD; 83695; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015878; -.
DR   VGNC; VGNC:33941; RHNO1.
DR   eggNOG; ENOG502S7M3; Eukaryota.
DR   GeneTree; ENSGT00390000003219; -.
DR   HOGENOM; CLU_075584_0_0_1; -.
DR   InParanoid; Q1LZE2; -.
DR   OMA; LTRECPR; -.
DR   OrthoDB; 1140824at2759; -.
DR   TreeFam; TF336053; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000015878; Expressed in semen and 104 other tissues.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
DR   GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0070318; P:positive regulation of G0 to G1 transition; IEA:Ensembl.
DR   GO; GO:0000725; P:recombinational repair; IBA:GO_Central.
DR   InterPro; IPR029293; RHNO1.
DR   PANTHER; PTHR35541; PTHR35541; 1.
DR   Pfam; PF15319; RHINO; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Chromosome; DNA damage; Nucleus; Reference proteome.
FT   CHAIN           1..241
FT                   /note="RAD9, HUS1, RAD1-interacting nuclear orphan protein
FT                   1"
FT                   /id="PRO_0000263104"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          68..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..88
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..115
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   241 AA;  27324 MW;  4B3ECB9984DB7A54 CRC64;
     MPPRKKRRQA AQKPQLLFHQ QPLEAPKHRC RFPQLPVVTH TRQVPSKPVD HNTITSWVSP
     QFDTTAESWF PGKRKHHHRD HARRSSRKST SSRFPCLTFE TPQSSASSAT PGILASRDGP
     SQPEKDISGR PLVPMLSPQS CRELSAHTFP DFPCVFIPPD IQTPESPGQG EPIPSELREN
     SLPSCSLHTS TPKSPEPGPV LVTDTPEEKY GIKVTWRRRR HLFAYLRERG KLSRSQFLVK
     D