RHNO1_RAT
ID RHNO1_RAT Reviewed; 235 AA.
AC Q6AY26;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=RAD9, HUS1, RAD1-interacting nuclear orphan protein 1;
GN Name=Rhno1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Brown Norway; TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in DNA damage response (DDR) signaling upon
CC genotoxic stresses such as ionizing radiation (IR) during the S phase.
CC Recruited to sites of DNA damage through interaction with the 9-1-1
CC cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent
CC manner. Required for the progression of the G1 to S phase transition.
CC Plays a role in the stimulation of CHEK1 phosphorylation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RAD9A, RAD18, TOPBP1 and UBE2N. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC Note=Localizes to sites of DNA damage in a H2AX-independent manner.
CC {ECO:0000250}.
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DR EMBL; BC079219; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q6AY26; -.
DR STRING; 10116.ENSRNOP00000036772; -.
DR PaxDb; Q6AY26; -.
DR Ensembl; ENSRNOT00000039086; ENSRNOP00000036772; ENSRNOG00000028517.
DR RGD; 1359404; Rhno1.
DR eggNOG; ENOG502S7M3; Eukaryota.
DR GeneTree; ENSGT00390000003219; -.
DR HOGENOM; CLU_075584_0_0_1; -.
DR InParanoid; Q6AY26; -.
DR OMA; VCPQFET; -.
DR PhylomeDB; Q6AY26; -.
DR TreeFam; TF336053; -.
DR Reactome; R-RNO-5685938; HDR through Single Strand Annealing (SSA).
DR Reactome; R-RNO-5693607; Processing of DNA double-strand break ends.
DR Reactome; R-RNO-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-RNO-69473; G2/M DNA damage checkpoint.
DR PRO; PR:Q6AY26; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000028517; Expressed in thymus and 20 other tissues.
DR Genevisible; Q6AY26; RN.
DR GO; GO:0005694; C:chromosome; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0071479; P:cellular response to ionizing radiation; ISO:RGD.
DR GO; GO:0034644; P:cellular response to UV; ISO:RGD.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; ISO:RGD.
DR GO; GO:0070318; P:positive regulation of G0 to G1 transition; ISO:RGD.
DR GO; GO:0000725; P:recombinational repair; ISO:RGD.
DR InterPro; IPR029293; RHNO1.
DR PANTHER; PTHR35541; PTHR35541; 1.
DR Pfam; PF15319; RHINO; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Chromosome; DNA damage; Nucleus; Reference proteome.
FT CHAIN 1..235
FT /note="RAD9, HUS1, RAD1-interacting nuclear orphan protein
FT 1"
FT /id="PRO_0000263107"
FT REGION 66..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 235 AA; 27070 MW; 8DFA9D605D105FCE CRC64;
MPPRKRRRQC QKAQLLFHQQ PLEGPKPHYE SHQQPITHTV QVPSKPIDQS TITSWVLPQF
DTAAESRFPT HRKHHRDQAR HPTRRSTCKF PRLTFESPES SSSETLLLSN REQLQNSEKD
APRRPLVPLF SPQSCGELSV HVPQSLPHVF MPPDIQTPGS SVREDPISPD QKENSLPSCI
LGPRTPRTPE PGPVLVKDTP EEKYGIKVTW RRRRHLFAYL KERGKLDKSQ FLVKT
