ID   RHO1_ENTHI              Reviewed;         208 AA.
AC   P31021;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Ras-like GTP-binding protein RHO1;
GN   Name=RHO1;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RX   PubMed=8459832; DOI=10.1016/0166-6851(93)90104-6;
RA   Lohia A., Samuelson J.;
RT   "Molecular cloning of a rho family gene of Entamoeba histolytica.";
RL   Mol. Biochem. Parasitol. 58:177-180(1993).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC       {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; L03809; AAA29114.1; -; Genomic_DNA.
DR   EMBL; L03809; AAA29115.1; -; Genomic_DNA.
DR   AlphaFoldDB; P31021; -.
DR   SMR; P31021; -.
DR   STRING; 5759.rna_EHI_015440-1; -.
DR   PRIDE; P31021; -.
DR   VEuPathDB; AmoebaDB:EHI5A_260040; -.
DR   VEuPathDB; AmoebaDB:EHI7A_021100; -.
DR   VEuPathDB; AmoebaDB:EHI8A_014430; -.
DR   VEuPathDB; AmoebaDB:EHI_015440; -.
DR   VEuPathDB; AmoebaDB:KM1_026260; -.
DR   eggNOG; KOG0393; Eukaryota.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   PANTHER; PTHR24072; PTHR24072; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding.
FT   CHAIN           1..208
FT                   /note="Ras-like GTP-binding protein RHO1"
FT                   /id="PRO_0000198887"
FT   MOTIF           49..57
FT                   /note="Effector region"
FT                   /evidence="ECO:0000255"
FT   BINDING         27..34
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         132..135
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   208 AA;  23220 MW;  AF24D5821717200F CRC64;
     MLAFSDMNTG AGKIENGKKA LKIVVVGDGA VGKTCLLLAF SKGEIPTAYV PTVFENFSHV
     MKYKNEEFIL DLWDTAGQEE YDRLRPLSYA DSDVVLLCFA VNNRTSFDNI STKWEPEIKH
     LYLILQRLKV DLRKDVSDDV TKQEGDDLCQ KLGCVAYIEA SSVAKIGLNE VFEKSVDCIF
     SNKPVPKASV TTQAKSQEVC FFIFLLLV