ID   RHO3_SCHCO              Reviewed;         206 AA.
AC   Q9P8J9;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=GTP-binding protein Rho3;
DE   Flags: Precursor;
GN   Name=RHO3;
OS   Schizophyllum commune (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX   NCBI_TaxID=5334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gorfer M., Uuskallio M., Raudaskoski M.;
RT   "Schizophyllum commune rho3-expression is elevated during mating
RT   interaction.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC       {ECO:0000305}.
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DR   EMBL; AF242543; AAF61254.1; -; mRNA.
DR   AlphaFoldDB; Q9P8J9; -.
DR   SMR; Q9P8J9; -.
DR   PRIDE; Q9P8J9; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   PANTHER; PTHR24072; PTHR24072; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW   Nucleotide-binding; Prenylation.
FT   CHAIN           1..203
FT                   /note="GTP-binding protein Rho3"
FT                   /id="PRO_0000198939"
FT   PROPEP          204..206
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250|UniProtKB:P62745"
FT                   /id="PRO_0000281269"
FT   MOTIF           46..54
FT                   /note="Effector region"
FT   BINDING         24..31
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P61586"
FT   BINDING         71..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P20171"
FT   BINDING         129..132
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P61586"
FT   MOD_RES         203
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250|UniProtKB:P62745"
FT   LIPID           203
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250|UniProtKB:P62745"
SQ   SEQUENCE   206 AA;  23235 MW;  DC1EA667BDBD2BC3 CRC64;
     MALCGSSKGR GRGRPIQRKV VVCGDGACGK TSLLNVFTRG FFTQVYEPTV FENYVHDLYI
     DDQLVELSLW DTAGQEEFDR LRSLSYAETH VIMICFSVDN PTSLENVESK WLDEILEYCP
     GVKLVLVDSK CDLRDDPAVL DRLQRYGTHT DQYEEGLGVA RRIRASRYLE CSSKHNRGVN
     EVFLRGRARV TVHSIRQGSA GSCCVM